MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism.
MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism.
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DOI：
10.3892/mmr.2018.8399
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发表时间：
2018-03
影响因子：
3.4
通讯作者：
Han YD
中科院分区：
文献类型：
--
作者：
Zhang HF;Wang YC;Han YD
微RNA（miRs）已被提议作为各种类型癌症的微创预后标志物，包括肝癌，肝癌是世界上最常见的癌症之一。本研究检测了miR-34 a在人肝癌组织和细胞系中的表达，并探讨了miR-34 a对肝癌细胞增殖、侵袭和糖酵解的影响。结果表明，miR-34 a在人肝癌组织中表达下调。过表达miR-34 a显著抑制肝癌细胞增殖和克隆形成。在潜在机制方面，miR-34 a被指示负调节乳酸脱氢酶A（LDHA）的表达，从而抑制癌细胞中LDHA依赖性葡萄糖摄取以及细胞增殖和侵袭。总的来说，这些数据表明，miR-34 a作为葡萄糖代谢的负调节剂发挥作用，并可能作为肝癌预后的新标志物。
MicroRNAs (miRs) have been proposed as minimally invasive prognostic markers for various types of cancer, including liver cancer, which is one of the most common cancers worldwide. In the present study, the expression of miR-34a in human liver cancer tissues and cell lines was evaluated and the effects of miR-34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. The results indicated that miR-34a was downregulated in human liver cancer tissues. Overexpression of miR-34a significantly inhibited liver cancer cell proliferation and clone formation. In terms of the underlying mechanism, miR-34a was indicated to negatively regulate the expression of lactate dehydrogenase A (LDHA), which consequently inhibited LDHA-dependent glucose uptake in the cancer cells, as well as cell proliferation and invasion. Collectively, these data suggest that miR-34a functions as a negative regulator of glucose metabolism and may serve as a novel marker for liver cancer prognosis.
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影响因子：
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通讯作者：
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