Repair of O4-alkylthymine damage in human cells.
Repair of O4-alkylthymine damage in human cells.
复制标题
修复人体细胞中O4-烷基胸腺嘧啶损伤。
DOI：
10.1007/978-1-4613-0637-5_32
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
D'Ambrosio,SM
中科院分区：
文献类型：
--
作者：
Wani,AA;Wani,G;D'Ambrosio,SM
Experiments using various test systems have demonstrated that agents with carcinogenic potential are also mutagenic in both prokaryotic and eukaryotic systems (Ames, 1979; Moore et al., 1988; Yuspa et al., 1989). Model studies using experimental animals and cultured cells associate the initiation step in the process of multistage carcinogenesis, with the structural alterations of the cellular DNA (Harris and Autrup, 1983; Cairns, 1981). The modifications of DNA structure can ultimately lead to abnormal cellular function unless the induced damage is repaired prior to the commencement of the cellular DNA replication. DNA alkylating agents e.g., nitrosoureas or nitrosoguanidines are a class of chemical compounds that mediate their biological effects through interactions with nucleophilic sites in DNA and formation of alkyl adducts. The chemistry and extent of formation of these adducts as well as their subsequent fate in the living cell plays a critical role in the mutagenic and carcinogenic processes (Margison and O’Connor, 1979; O’Connor et al., 1979). Elucidation of the mechanism(s), by which a variety of different adducts elicit changes in cellular phenotype, has been an area of intense pathobiological investigation. In-depth studies have been performed on the chemistry and reactivity of different alkylation agents.
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影响因子：
5
作者：
FERENCZ, C;RUBIN, JD;DOWNING, JW
通讯作者：
DOWNING, JW
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
1.9
作者：
BONNEY, GE
通讯作者：
BONNEY, GE
血流动力学和心脏发生：生理因素对心脏发育的影响。
DOI：
--
发表时间：
1978
期刊：
Birth defects original article series
影响因子：
--
作者：
D. C. Jaffee
通讯作者：
D. C. Jaffee
复发风险
影响因子：
5.2
作者：
Shelley D. Smith
通讯作者：
Shelley D. Smith