Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations
Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations
复制标题
精神分裂症侧脑室大小：与疾病过程及其临床表现的关系
作者：
D. Owens;E. Johnstone;T. Crow;C. Frith;J. Jagoe;L. Kreel
概要 使用计算机断层扫描技术，对 112 名住院慢性精神分裂症患者（从 510 例中选择，以研究缺陷状态和智力下降的相关性以及胰岛素、电休克和安定药物治疗的影响）的侧脑室大小进行了研究，并与非住院精神分裂症患者、首次精神分裂症发作患者、住院患者和非住院患者的匹配组进行比较原发性情感障碍和神经症门诊患者。年龄与侧脑室大小显着相关（P < 0·0002），但考虑到年龄时，住院精神分裂症患者的侧脑室明显大于神经症患者（P < 0·025）。心室扩大与过去的物理治疗（精神安定药、胰岛素昏迷和电休克治疗）无关。在住院的精神分裂症患者群体中，几乎没有发现与心室扩大的相关性。因此，在这个人群中，心室大小的增加与缺陷状态的特征（阴性症状和智力障碍）没有明显的相关性。然而，智力功能和心室大小之间存在曲线（倒U）关系，与幻觉的消失、社会行为障碍、不活动和异常不自主运动的存在显着相关。研究结果证实，慢性精神分裂症确实发生了大脑结构的变化，但也说明了阐明脑室扩大的临床意义的一些困难。横向非双峰；与疾病特定特征的关系很复杂，并且可能只有在大样本量的研究中才会出现。
Synopsis Using computed tomography, lateral ventricular size was studied in a sample of 112 institutionalized chronic schizophrenic patients (selected from 510 cases to investigate the correlates of the defect state and intellectual decline and the effects of insulin, electroconvulsive and neuroleptic treatment), and compared with matched groups of non-institutionalized schizophrenics, patients with first schizophrenic episodes, institutionalized and non-institutionalized patients with primary affective disorder, and neurotic out-patients. Age was significantly correlated (P < 0·0002) with lateral ventricular size, but the institutionalized schizophrenic patients had significantly larger (P < 0·025) lateral ventricles than the neurotics when age was taken into account. Ventricular enlargement was unrelated to past physical treatment (neuroleptics, insulin coma and electroconvulsive therapy). Within the group of institutionalized schizophrenic patients few correlates of ventricular enlargement were identified; thus in this population increased ventricular size was not clearly associated with the features of the defect state (negative symptoms and intellectual impairment). however, there was a curvilinear (inverted-U) relationship between intellectual function and ventricular size was significantly related to absence of hallucinations, impairment of social behaviour, inactivity and the presence of abnormal involuntary movements. The findings confirm that structural brain changes do occur in chronic schizophrenia, but illustrate some of the difficulties in elucidating the clinical significance of ventricular enlargement. Lateral not bimodal; the relationship to particular features of the disease is complex and likely to emerge only in studies with a large sample size.
精神分裂症的心室扩大：与阳性和阴性症状的关系。
DOI：
10.1176/ajp.139.3.297
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen,NC;Olsen,SA;Dennert,JW;Smith,MR
通讯作者：
Smith,MR