Role of natural killer and dendritic cell crosstalk in immunomodulation by commensal bacteria probiotics.
Role of natural killer and dendritic cell crosstalk in immunomodulation by commensal bacteria probiotics.
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DOI：
10.1155/2011/473097
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发表时间：
2011
影响因子：
--
通讯作者：
Ferlazzo G
中科院分区：
文献类型：
--
作者：
Rizzello V;Bonaccorsi I;Dongarrà ML;Fink LN;Ferlazzo G
近年来，自然杀伤细胞（NK）和树突状细胞（DC）之间的合作对话已得到阐明。它们相互帮助，以获得其完整的功能，无论是在外周和次级淋巴器官。因此，NK细胞被树突状细胞激活允许杀伤外周中的转化或感染细胞，但对于产生适应性免疫也可能是重要的。事实上，已经显示NK细胞在与暴露于微生物产物的DC相互作用后极化Th 1应答中可能起关键作用。DC/NK串扰的这种调节作用在粘膜表面如肠中特别重要，其中免疫系统与肠道细菌如乳酸菌（LAB）密切相关。我们在这里审查NK/DC相互作用的存在下，肠源性大肠杆菌和细菌菌株依赖的免疫调节作用中的作用。我们特别旨在强调不同种类的肠道细菌益生菌以不同方式影响DC/NK串扰结果的能力，并因此以不同方式影响适应性免疫应答的极化。
A cooperative dialogue between natural killer (NK) cells and dendritic cells (DCs) has been elucidated in the last years. They help each other to acquire their complete functions, both in the periphery and in the secondary lymphoid organs. Thus, NK cells' activation by dendritic cells allows the killing of transformed or infected cells in the periphery but may also be important for the generation of adaptive immunity. Indeed, it has been shown that NK cells may play a key role in polarizing a Th1 response upon interaction with DCs exposed to microbial products. This regulatory role of DC/NK cross-talk is of particular importance at mucosal surfaces such as the intestine, where the immune system exists in intimate association with commensal bacteria such as lactic acid bacteria (LAB). We here review NK/DC interactions in the presence of gut-derived commensal bacteria and their role in bacterial strain-dependent immunomodulatory effects. We particularly aim to highlight the ability of distinct species of commensal bacterial probiotics to differently affect the outcome of DC/NK cross-talk and consequently to differently influence the polarization of the adaptive immune response.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
--
作者：
Fink, Lisbeth N.;Zeuthen, Louise H.;Frokiaer, Hanne
通讯作者：
Frokiaer, Hanne
影响因子：
15.9
作者：
Becker, C;Wirtz, S;Neurath, MF
通讯作者：
Neurath, MF
影响因子：
4.4
作者：
Christensen, HR;Frokiær, H;Pestka, JJ
通讯作者：
Pestka, JJ
影响因子：
7
作者：
Bailey, M;Haverson, K;Stokes, C
通讯作者：
Stokes, C