MicroRNA-940 as a Potential Serum Biomarker for Prostate Cancer.
MicroRNA-940 as a Potential Serum Biomarker for Prostate Cancer.
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DOI：
10.3389/fonc.2021.628094
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chaudhary P
中科院分区：
文献类型：
--
作者：
Rajendiran S;Maji S;Haddad A;Lotan Y;Nandy RR;Vishwanatha JK;Chaudhary P
前列腺癌是导致死亡的主要原因之一，尽管局部肿瘤的存活率高得惊人。虽然前列腺特异性抗原（PSA）测试，与直肠指检结合进行，是相当准确的，有主要的警告，需要进行测试之前的风险和利益进行彻底的评估。MicroRNA是一类非编码小分子RNA，是一种稳定的分子，可以通过非侵入性方法在循环中检测到，近年来在癌症预后和诊断中发挥了重要作用。在这里，我们研究了循环miR-940，一种已知在前列腺癌进展中起作用的miRNA，在细胞培养上清液以及患者血清和尿液样本中，以确定miR-940作为前列腺癌检测的新分子标记物的效用。我们发现miR-940在癌症患者的血清中显著较高，特别是具有临床意义的肿瘤（GS ≥ 7）的患者。受试者工作特征曲线分析表明，miR-940联合PSA诊断前列腺癌的曲线下面积值（AUC：0.818）高于miR-940单独治疗（AUC：0.75）。这项研究提供了有希望的结果，表明miR-940用于前列腺癌诊断。
Prostate cancer is one of the leading causes of death despite an astoundingly high survival rate for localized tumors. Though prostate specific antigen (PSA) test, performed in conjunction with digital rectal examinations, is reasonably accurate, there are major caveats requiring a thorough assessment of risks and benefits prior to conducting the test. MicroRNAs, a class of small non-coding RNAs, are stable molecules that can be detected in circulation by non-invasive methods and have gained importance in cancer prognosis and diagnosis in the recent years. Here, we investigate circulating miR-940, a miRNA known to play a role in prostate cancer progression, in both cell culture supernatants as well as patient serum and urine samples to determine the utility of miR-940 as a new molecular marker for prostate cancer detection. We found that miR-940 was significantly higher in serum from cancer patients, specifically those with clinically significant tumors (GS ≥ 7). Analysis of receiver operating characteristic curve demonstrated that miR-940 in combination with PSA had a higher area under curve value (AUC: 0.818) than the miR-940 alone (AUC: 0.75) for the diagnosis of prostate cancer. This study provides promising results suggesting the use of miR-940 for prostate cancer diagnosis.
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影响因子：
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