Parkinson's disease differentially affects adaptation to gradual as compared to sudden visuomotor distortions.
Parkinson's disease differentially affects adaptation to gradual as compared to sudden visuomotor distortions.
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DOI：
10.1016/j.humov.2010.08.020
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发表时间：
2011-08
影响因子：
2.1
通讯作者：
Contreras-vidal, Jose L.
中科院分区：
文献类型：
--
作者：
Venkatakrishnan, Anusha;Banquet, Jean P.;Burnod, Yves;Contreras-vidal, Jose L.
帕金森病（PD）患者在运动适应方面存在困难，难以在新的环境背景下优化性能，例如改变屏幕光标-手的关系。先前的研究表明，失真的时间过程差异影响视觉适应屏幕光标旋转，这表明渐进和突然适应的不同机制。此外，对人类和非人类灵长类动物的研究表明，对突然运动学扭曲的适应可能涉及基底神经节，而对渐进运动学扭曲的适应则涉及小脑结构。在本研究中，参与者是PD患者，他们在正常或旋转屏幕光标反馈条件下使用数字化仪平板电脑和笔或计算机轨迹球进行中心向外指向运动。最初的研究使用交叉实验设计测试了PD患者对逐渐适应与突然旋转的手-屏幕光标关系的适应，并仅显示了逐渐适应任务的显著后效。与这些结果一致，使用轨迹球进行的随访实验结果显示，与年龄匹配的健康对照组相比，PD患者更好地适应渐进式干扰，而不是突然干扰。我们的结论是，帕金森氏病影响适应突然的视觉扭曲，但备件适应逐渐扭曲。
Patients with Parkinson’s disease (PD) have difficulties in movement adaptation to optimize performance in novel environmental contexts such as altered screen cursor-hand relationships. Prior studies have shown that the time course of the distortion differentially affects visuomotor adaptation to screen cursor rotations, suggesting separate mechanisms for gradual and sudden adaptation. Moreover, studies in human and non-human primates suggest that adaptation to sudden kinematic distortions may engage the basal ganglia, whereas adaptation to gradual kinematic distortions involves cerebellar structures. In the present studies, participants were patients with PD, who performed center-out pointing movements, using either a digitizer tablet and pen or a computer trackball, under normal or rotated screen cursor feedback conditions. The initial study tested patients with PD using a cross-over experimental design for adaptation to gradual as compared with sudden rotated hand-screen cursor relationships and revealed significant after-effects for the gradual adaptation task only. Consistent with these results, findings from a follow-up experiment using a trackball that required only small finger movements showed that patients with PD adapt better to gradual as against sudden perturbations, when compared to age-matched healthy controls. We conclude that Parkinson’s disease affects adaptation to sudden visuomotor distortions but spares adaptation to gradual distortions.
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影响因子：
1.7
作者：
Robertson, EM;Miall, RC
通讯作者：
Miall, RC
DOI：
10.1016/0926-6410(95)90014-4
发表时间：
1995-10-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
ROBYBRAMI, A;BURNOD, Y
通讯作者：
BURNOD, Y
影响因子：
2.5
作者：
Criscimagna-Hemminger, Sarah E.;Bastian, Amy J.;Shadmehr, Reza
通讯作者：
Shadmehr, Reza
影响因子：
5.3
作者：
Mandelblat-Cerf, Yael;Paz, Rony;Vaadia, Eilon
通讯作者：
Vaadia, Eilon
影响因子：
64.8
作者：
Thoroughman, KA;Shadmehr, R
通讯作者：
Shadmehr, R