Recurrent medulloepithelioma of the ciliary body. Immunohistochemical characteristics.
Recurrent medulloepithelioma of the ciliary body. Immunohistochemical characteristics.
复制标题
复发性睫状体髓质上皮瘤。
DOI：
10.1016/s0161-6420(88)32972-6
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发表时间：
1988
期刊：
影响因子：
13.7
通讯作者：
A. Tarkkanen
中科院分区：
文献类型：
--
作者：
T. Kivelä;A. Tarkkanen
一名 8 岁女孩被诊断出主要为良性的睫状体髓质上皮瘤，并通过虹膜环切除术切除了该瘤。 30个月内复发两次。出现了高度恶性的组织病理学特征，眼睛最终穿孔并不得不被摘除。随后未出现复发或转移。组织学上，该肿瘤是一种非畸胎样髓质上皮瘤，由类似于胚胎视网膜、非色素性睫状上皮和神经母细胞的成分组成，但根据免疫组织化学判断，也具有明显的神经胶质和神经元分化区域。神经上皮肿瘤细胞对神经元特异性烯醇化酶、波形蛋白呈阳性，并且通常对 S-100 蛋白呈阳性。神经母细胞通常对神经元特异性烯醇化酶和突触素呈阳性，但与对波形蛋白、神经胶质纤维酸性蛋白和S-100蛋白呈阳性的神经胶质样肿瘤细胞混合。结果表明，与视网膜母细胞瘤不同，即使是非畸形样髓质上皮瘤也可能是真正的多能肿瘤。
A predominantly benign medulloepithelioma of the ciliary body was diagnosed in an 8-year-old girl and resected by iridocyclectomy. It recurred twice during 30 months. Highly malignant histopathologic features developed, and the eye finally perforated and had to be enucleated. No recurrence or metastases have subsequently developed. Histologically, the tumor was a nonteratoid medulloepithelioma consisting of elements resembling embryonic retina, nonpigmented ciliary epithelium, and neuroblasts, but had also areas of obvious glial and neuronal differentiation as judged by immunohistochemistry. The neuroepithelial tumor cells were positive for neuron-specific enolase, vimentin, and often for S-100 protein. The neuroblastic cells were generally positive for neuronspecific enolase and synaptophysin, but were intermixed with glia-like tumor cells positive for vimentin, glial fibrillary acidic protein, and S-100 protein. The results suggest that even a nonteratoid medulloepithelioma may be, unlike retinoblastoma, a truly multipotential tumor.
三侧视网膜母细胞瘤中的 S 抗原免疫反应性。
影响因子：
4.2
作者：
Donoso,LA;Rorke,LB;Shields,JA;Augsburger,JJ;Brownstein,S;Lahoud,S
通讯作者：
Lahoud,S