Expanding the repertoire of intermuscular coordination patterns and modulating intermuscular connectivity in stroke-affected upper extremity through electromyogram-guided training: a pilot study
Expanding the repertoire of intermuscular coordination patterns and modulating intermuscular connectivity in stroke-affected upper extremity through electromyogram-guided training: a pilot study
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通过肌电图引导训练扩大中风影响上肢的肌间协调模式并调节肌间连接：一项试点研究
DOI：
10.1109/embc40787.2023.10341085
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Roh, Jinsook
中科院分区：
文献类型：
--
作者：
Seo, Gang;Houston, Michael;Portilla, Manuel;Fang, Feng;Park, Jeong-Ho;Lee, Hangil;Li, Sheng;Park, Hyung-Soon;Zhang, Yingchun;Roh, Jinsook
肌肉间协调异常是卒中所致上肢(UE)功能运动障碍的主要原因。以前的研究已经通过计算确定了中风影响的UE中肌肉间协调的异常及其对运动输出的负面影响。因此，靶向异常肌肉协同作用有可能成为卒中康复的有效途径。最近，我们通过肌电(EMG)信号引导的训练方案验证了UE中年轻健全成年人自然表达的肌肉协同效应的可修复性。这项研究测试了肌电引导的运动是否会诱导新的肌肉协同效应，改变相关的肌肉间连接，并改善中风影响的中到重度运动障碍的UE的运动结果。这项研究使用了为期六周的等长肌电信号引导的锻炼方案，重点是独立激活两块特定的肌肉，即二头肌和肱二头肌，以开发新的肌肉激活组。研究发现，中风组和年龄匹配的健全组都能够在习惯性肌肉激活的情况下，通过锻炼发展出新的肌肉协调模式，这导致训练后手臂的运动控制能力有所改善。此外，研究结果还提供了初步证据，表明训练后中风患者的目标肌肉之间在β频段频率上的肌肉间连通性增加，这表明共同的神经驱动受到了调制。这些发现表明，我们的等长运动方案有可能通过扩展UE的肌肉间协调能力来改善中风幸存者的日常生活活动(ADL)中的表现，并最终提高他们的生活质量。临床相关性--本研究表明，通过等长肌电引导的运动对任务表现和肌肉间连通性产生积极影响，扩大中风患者UE的肌肉间协调模式是可行的。
Abnormal intermuscular coordination is a major stroke-induced functional motor impairment in the upper extremity (UE). Previous studies have computationally identified the abnormalities in the intermuscular coordination in the stroke-affected UE and their negative impacts on motor outputs. Therefore, targeting the aberrant muscle synergies has the potential as an effective approach for stroke rehabilitation. Recently, we verified the modifiability of the naturally expressed muscle synergies of young able-bodied adults in UE through an electromyographic (EMG) signal-guided exercise protocol. This study tested if an EMG-guided exercise will induce new muscle synergies, alter the associated intermuscular connectivity, and improve UE motor outcome in stroke-affected UE with moderate-to-severe motor impairment. The study used the six-week isometric EMG signal-guided exercise protocol that focused on independently activating two specific muscles, the biceps and brachioradialis, to develop new muscle activation groups. The study found that both the stroke and age-matched, able-bodied groups were able to develop new muscle coordination patterns through the exercise while habitual muscle activation was still available, which led to improvements in the motor control of the trained arm. In addition, the results provided preliminary evidence of increased intermuscular connectivity between targeted muscles in the beta-band frequencies for stroke patients after training, suggesting a modulation of the common neural drive. These findings suggest that our isometric exercise protocol has the potential to improve stroke survivors' performance of UE in their activities in daily lives (ADLs) and, ultimately, their quality of life through expanding their repertoire of intermuscular coordination.Clinical Relevance— This study shows the feasibility of expanding the intermuscular coordination pattern in stroke-affected UE through an isometric EMG-guided exercise which positively affects task performance and intermuscular connectivity.
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DOI：
10.1093/brain/aws150
发表时间：
2012-09
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Fisher KM;Zaaimi B;Williams TL;Baker SN;Baker MR
通讯作者：
Baker MR
影响因子：
4.3
作者：
Ferrante S;Chia Bejarano N;Ambrosini E;Nardone A;Turcato AM;Monticone M;Ferrigno G;Pedrocchi A
通讯作者：
Pedrocchi A
DOI：
10.1109/tnsre.2021.3075907
发表时间：
2021-01-01
影响因子：
4.9
作者：
Houston, Michael;Li, Xiaoyan;Zhang, Yingchun
通讯作者：
Zhang, Yingchun
肌肉协同作用的时间控制与α波段神经驱动有关。
影响因子：
5.5
作者：
Laine, Christopher M.;Cohn, Brian A.;Valero-Cuevas, Francisco J.
通讯作者：
Valero-Cuevas, Francisco J.
影响因子：
4.6
作者：
Pellegrino L;Coscia M;Muller M;Solaro C;Casadio M
通讯作者：
Casadio M