Exploratory randomized controlled trial evaluating the impact of a waiting list control design.

Exploratory randomized controlled trial evaluating the impact of a waiting list control design.
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DOI:
10.1186/1471-2288-13-150
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发表时间:
2013-12-06
影响因子:
4
通讯作者:
McCambridge J
McCambridge J
中科院分区:
医学3区
文献类型:
--
作者:
Cunningham JA;Kypri K;McCambridge J

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在心理和行为干预研究中采用等候名单控制设计可能会人为地夸大干预效果的估计。这项探索性随机对照试验在一项对问题饮酒者进行短暂干预的研究中验证了这一命题,问题饮酒者是使用等候名单控制设计的研究领域之一。所有参与者(N = 185)在被随机分配后,要么被告知他们处于干预条件下,这就是干预,要么被告知他们处于等待名单控制条件下,他们将在四周内获得干预的访问权,同时提供这些信息。4周后,共有157名参与者(85%)接受了随访。四项结果(安全饮酒指南内的比例)中的一项存在组间差异。在实验操作和研究开始时的变化阶段之间确定了一种相互作用,这样参与者的变化在那些更愿意改变的人中被阻止,并被告知他们在等待名单上。等候名单对照条件的试验可能高估了治疗效果,尽管这种偏差的程度可能因研究人群而异。可以说,只有在仔细评估了对有效推理的威胁的情况下,才应该使用它们。
Employing waiting list control designs in psychological and behavioral intervention research may artificially inflate intervention effect estimates. This exploratory randomized controlled trial tested this proposition in a study employing a brief intervention for problem drinkers, one domain of research in which waiting list control designs are used. All participants (N = 185) were provided with brief personalized feedback intervention materials after being randomly allocated either to be told that they were in the intervention condition and that this was the intervention or to be told that they were in the waiting list control condition and that they would receive access to the intervention in four weeks with this information provided in the meantime. A total of 157 participants (85%) were followed-up after 4 weeks. Between-group differences were found in one of four outcomes (proportion within safe drinking guidelines). An interaction was identified between experimental manipulation and stage of change at study entry such that participant change was arrested among those more ready to change and told they were on the waiting list. Trials with waiting list control conditions may overestimate treatment effects, though the extent of any such bias appears likely to vary between study populations. Arguably they should only be used where this threat to valid inference has been carefully assessed.
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发表时间: 2011
期刊: PloS one
影响因子: 3.7
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期刊: ADDICTION
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影响因子: 4.4
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