Comparison of Selenite and Selenate Apparent Absorption and Retention in Infants Using Stable Isotope Methodology
Comparison of Selenite and Selenate Apparent Absorption and Retention in Infants Using Stable Isotope Methodology
复制标题
使用稳定同位素方法比较婴儿中亚硒酸盐和硒酸盐的表观吸收和保留
作者：
P. Dael;L. Davidsson;E. Ziegler;L. Fay;D. Barclay
无机硒化合物亚硒酸盐和硒酸盐用于婴儿配方奶粉的硒强化。然而，缺乏有关从这些化合物中吸收和保留硒的信息。因此，本研究的目的是确定健康婴儿对添加到婴儿配方奶粉中的硒酸盐和亚硒酸盐的硒的表观吸收和保留情况。通过将 10 μg Se 作为 76Se-硒酸盐或 74Se-亚硒酸盐添加到 500 mL 配方奶粉中来制备标记的测试餐。在平衡期的第一天，将两批标记的配方奶作为替代饲料饲喂，然后饲喂未标记的配方奶。在摄入后 72 小时收集的粪便和连续 3 次 24 小时收集的尿液中测定硒同位素。 76Se-亚硒酸盐的平均表观吸收率为 97.1%，74Se-亚硒酸盐的平均表观吸收率为 73.4%；平均差异 23.7%（范围：13.8%–35.7%；SD 6.8%，p < 0.001）。平均尿排泄（摄入剂量的%）为36.4%（76Se-亚硒酸盐）和9.7%（74Se-亚硒酸盐）；平均差异 26.7%（范围：13.9%–36.5%；SD 5.9%，p < 0.001）。 76Se-硒酸盐和 74Se-亚硒酸盐的硒平均表观保留率没有显着差异，分别为 60.7%（76Se-亚硒酸盐）和 63.7%（74Se-亚硒酸盐）。平均差异为−3.01%（范围：−14.0%–12.0%；SD 9.4%，p = 0.36）。尽管亚硒酸盐和硒酸盐的表观硒吸收和尿排泄不同，但婴儿从这两种硒化合物中保留的硒效果相同。因此，我们得出的结论是，婴儿配方奶粉中添加硒酸盐或亚硒酸盐预计会对足月婴儿的硒营养状况产生类似的影响。
The inorganic selenium compounds selenite and selenate are used for selenium fortification of infant formulas. However, information on absorption and retention of selenium from these compounds is lacking. The purpose of this study was therefore to determine apparent absorption and retention of selenium from selenate and selenite added to a milk-based infant formula in healthy infants. Labeled test meals were prepared by addition of 10 μg Se as 76Se-selenate or 74Se-selenite to 500 mL formula. The two batches of labeled formulas were fed as alternate feeds during the first day of the balance period, followed by unlabeled formula. Selenium isotopes were determined in feces collected for 72h after intake and in 3 consecutive 24h collections of urine. Mean apparent absorption was 97.1% for 76Se-selenate and 73.4% for 74Se-selenite; mean difference 23.7% (range: 13.8%–35.7%; SD 6.8%, p < 0.001). Mean urinary excretion (% of ingested dose) was 36.4% (76Se-selenate) and 9.7% (74Se-selenite); mean difference 26.7% (range: 13.9%–36.5%; SD 5.9%, p < 0.001). Mean apparent retention of selenium from 76Se-selenate and 74Se-selenite was not significantly different, 60.7% (76Se-selenate) versus 63.7% (for 74Se-selenite). The average difference was −3.01% (range: −14.0%–12.0%; SD 9.4%, p = 0.36). Although apparent selenium absorption and urinary excretion differed for selenite and selenate, selenium was equally well retained by infants from both selenium compounds. We therefore concluded that Se fortification of infant formulas with selenate or selenite can be expected to have similar impact on the selenium nutritional status of term infants.
母乳、早产配方奶粉或补硒早产配方奶粉喂养的早产儿的硒状况。
DOI：
10.1016/s0022-3476(05)82058-x
发表时间：
1991
期刊：
The Journal of pediatrics
影响因子：
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作者：
Smith,AM;Chan,GM;Moyer-Mileur,LJ;Johnson,CE;Gardner,BR
通讯作者：
Gardner,BR