Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review.
Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review.
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DOI：
10.1007/s00415-018-8768-0
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发表时间：
2018-07
影响因子：
6
通讯作者：
Lioutas VA
中科院分区：
文献类型：
--
作者：
Avgerinos KI;Kalaitzidis G;Malli A;Kalaitzoglou D;Myserlis PG;Lioutas VA
由于阿尔茨海默病（AD）与糖尿病（DM）的共同病理生理学发现，胰岛素已被建议作为AD或轻度认知障碍（MCI）的可能治疗。IV胰岛素的安全替代品是鼻内（IN）胰岛素。本系统评价的目的是研究胰岛素对AD或MCI患者认知功能的影响。对电子数据库Medline、Scopus和CENTRAL进行了文献检索，以识别研究IN胰岛素给药对AD或MCI患者认知任务影响的RCT。7项研究（293例患者）符合我们的纳入标准。大多数研究表明，胰岛素注射后，言语记忆，尤其是故事回忆得到改善。有时对apoE 4（-）患者的影响有限。鼻内胰岛素不影响其他认知功能。然而，在功能状态和日常活动方面有一些积极的结果。此外，数据表明，不同的胰岛素类型和剂量可能对不同的apoE 4组有不同的影响。此外，治疗对A β水平的影响因研究而异。最后，IN胰岛素产生了轻微的不良反应。鼻内胰岛素改善了apoe 4（-）AD或MCI患者的故事回忆表现。其他认知功能没有受到影响，但在功能状态和日常活动方面有一些积极的结果。由于IN胰岛素是一种安全的干预措施，未来的研究应使用更大的剂量，并在适当选择患者和胰岛素类型后进行。
Due to common pathophysiological findings of Alzheimer’s disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investigate the effects of IN insulin on cognitive function of patients with either AD or MCI. A literature search of the electronic databases Medline, Scopus and CENTRAL was performed in order to identify RCTs investigating the effect of IN insulin administration on cognitive tasks, in patients with AD or MCI. Seven studies (293 patients) met our inclusion criteria. Most studies showed that verbal memory and especially story recall was improved after IN insulin administration. Sometimes the effect was restricted for apoe4 (–) patients. Intranasal insulin did not affect other cognitive functions. However, there were some positive results in functional status and daily activity. Also, data suggested that different insulin types and doses may have different effects on different apoe4 groups. In addition, the effects of treatment on Αβ levels differed from study to study. Finally, IN insulin resulted in minor adverse effects. Intranasal insulin improved story recall performance of apoe4 (–) patients with AD or MCI. Other cognitive functions were not affected, but there were some positive results in functional status and daily activity. Since IN insulin is a safe intervention, future studies should be conducted with larger doses and after proper selection of patients and insulin types.
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影响因子：
3.7
作者：
Benedict, C;Hallschmid, M;Kern, W
通讯作者：
Kern, W
影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
DOI：
10.1111/j.1749-6632.2000.tb06371.x
发表时间：
2000-01-01
期刊：
VASCULAR FACTORS IN ALZHEIMER'S DISEASE
影响因子：
--
作者：
Craft, S;Asthana, S;Plymate, S
通讯作者：
Plymate, S
影响因子：
4.1
作者：
Craft, S;Asthana, S;Grimwood, K
通讯作者：
Grimwood, K
影响因子：
--
作者：
Craft, S;Asthana, S;Veith, RC
通讯作者：
Veith, RC