Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.
Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.
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DOI：
10.1016/j.yebeh.2015.01.006
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Benke TA
中科院分区：
文献类型：
--
作者：
Bernard PB;Castano AM;Beitzel CS;Carlson VB;Benke TA
我们探讨了出生后7天由红藻氨酸(KA-ELS)诱导的单次早期生活癫痫的发育和行为后果。发育轨迹的相关性没有改变，表明KA-ELS引起的长期后果不是由继发性原因引起的，如营养不良或母婴护理的改变。我们报告了成年大鼠大理石埋藏的减少，这暗示了受限的兴趣，这是实验性和临床自闭症的共同特征。在习惯性笼养行为中，我们没有检测到重复梳理的增加。然而，我们确实检测到成年KA-ELS大鼠在陌生大鼠存在的情况下梳毛能力下降，这支持KA-ELS后社交焦虑的改变。对一项社交方法任务的重新分析进一步表明了不正常的社交互动。结合以前的生理和行为数据，这些数据支持这样的假设，即KA-ELS导致成年大鼠潜在的自闭症表型，而不是归因于其他发育早期的变化。
We probed the developmental and behavioral consequences of a single early life seizure induced by kainic acid (KA-ELS) in the rat on post natal day 7. Correlates of developmental trajectory were not altered, demonstrating that long term consequences following KA-ELS are not initiated by secondary causes, such as malnourishment or alterations in maternal care. We report reduced marble burying in adult rats, suggestive of restricted interests, a trait common to experimental and clinical autism. We did not detect increased repetitive grooming during habituated cage behavior. However, we did detect reduced grooming in adult KA-ELS rats in the presence of an unfamiliar rat, supporting altered social anxiety following KA-ELS. Reanalysis of a social approach task further indicated abnormal social interactions. Taken together with previous physiological and behavioral data, these data support the hypothesis that KA-ELS lead to a latent autistic phenotype in adult rats not attributable to other early alterations in development.
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影响因子：
5.3
作者：
Bernard, Paul B.;Benke, Tim A.
通讯作者：
Benke, Tim A.
影响因子：
1.9
作者：
Harbert MJ;Tam EW;Glass HC;Bonifacio SL;Haeusslein LA;Barkovich AJ;Jeremy RJ;Rogers EE;Glidden DV;Ferriero DM
通讯作者：
Ferriero DM
DOI：
10.1016/j.yebeh.2011.07.022
发表时间：
2011-10
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Kleen JK;Sesqué A;Wu EX;Miller FA;Hernan AE;Holmes GL;Scott RC
通讯作者：
Scott RC
影响因子：
3.6
作者：
Glass HC;Hong KJ;Rogers EE;Jeremy RJ;Bonifacio SL;Sullivan JE;Barkovich AJ;Ferriero DM
通讯作者：
Ferriero DM
影响因子：
11.2
作者：
Holmes, GL;Gairsa, JL;Ben-Ari, Y
通讯作者：
Ben-Ari, Y