Hypothermia is correlated with seizure absence in perinatal stroke.
Hypothermia is correlated with seizure absence in perinatal stroke.
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DOI：
10.1177/0883073811408092
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发表时间：
2011-09
影响因子：
1.9
通讯作者：
Ferriero DM
中科院分区：
文献类型：
--
作者：
Harbert MJ;Tam EW;Glass HC;Bonifacio SL;Haeusslein LA;Barkovich AJ;Jeremy RJ;Rogers EE;Glidden DV;Ferriero DM
在一项包含315名受试者的新生儿脑病单中心前瞻性队列研究中，发现15名新生儿在MRI上有局灶性卒中。根据性别和脑病程度，将这15例病例与同一队列的30例无卒中新生儿进行匹配。使用贝利婴儿发育量表，中风组的精神发育指数评分低1.7个标准差（P=0.007）。在调整新生儿癫痫发作的存在后，不再观察到这种关联（P=0.11）。在15例中风患者中，5例接受了低温治疗。这5例患者在新生儿期均未发生癫痫发作，而未接受治疗的10例患者中有7例发生癫痫发作。这是第一项证明治疗性低温对围产期中风的潜在治疗效果的人类研究。此外，癫痫发作的存在与出现脑病的卒中的认知结果较差相关。
Within a single-center prospective cohort study of neonatal encephalopathy that contained 315 subjects, 15 neonates were found to have a focal stroke on MRI. These 15 cases were matched on the basis of gender and degree of encephalopathy to 30 neonates from the same cohort without stroke. Using the Bayley Scales of Infant Development, the stroke group had Mental Developmental Index scores that were 1.7 standard deviations lower (P=0.007.) This association was no longer seen after adjusting for the presence of neonatal seizures (P=0.11.) Of the 15 cases of stroke, 5 had been treated with hypothermia. None of these 5 had seizures in the neonatal period, compared to 7 of the untreated 10. This is the first human study to demonstrate a potential treatment effect of therapeutic hypothermia upon perinatal stroke. In addition the presence of seizures is associated with worse cognitive outcomes for stroke that presents with encephalopathy.
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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