Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).
复制标题
慢性肾脏疾病中冠状动脉钙化的候选基因关联研究：CRIC研究的发现（慢性肾功能不全队列）。
DOI：
10.1016/j.jacc.2013.01.103
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发表时间：
2013-08-27
影响因子：
24
通讯作者：
Reilly, Muredach P.
中科院分区：
文献类型：
--
作者：
Ferguson, Jane F.;Matthews, Gregory J.;Townsend, Raymond R.;Raj, Dominic S.;Kanetsky, Peter A.;Budoff, Matthew;Fischer, Michael J.;Rosas, Sylvia E.;Kanthety, Radhika;Rahman, Mahboob;Master, Stephen R.;Qasim, Atif;Li, Mingyao;Mehta, Nehal N.;Shen, Haiqing;Mitchell, Braxton D.;O'Connell, Jeffrey R.;Shuldiner, Alan R.;Ho, Weang Kee;Young, Robin;Rasheed, Asif;Danesh, John;He, Jiang;Kusek, John W.;Ojo, Akinlolu O.;Flack, John;Go, Alan S.;Gadegbeku, Crystal A.;Wright, Jackson T., Jr.;Saleheen, Danish;Feldman, Harold I.;Rader, Daniel J.;Foulkes, Andrea S.;Reilly, Muredach P.
关键词：
To identify loci for coronary artery calcification (CAC) in patients with chronic kidney disease (CKD). CKD is associated with increased CAC and subsequent coronary heart disease (CHD) but the mechanisms remain poorly defined. Genetic studies of CAC in CKD may provide a useful strategy for identifying novel pathways in CHD. We performed a candidate gene study (~2,100 genes; ~50,000 SNPs) of CAC within the Chronic Renal Insufficiency Cohort (CRIC) Study (n=1,509; 57% European, 43% African ancestry). SNPs with preliminary evidence of association with CAC in CRIC were examined for association with CAC in PennCAC (n=2,560) and Amish Family Calcification Study (AFCS; n=784) samples. SNPs with suggestive replication were further analyzed for association with myocardial infarction (MI) in the Pakistan Risk of Myocardial Infarction study (PROMIS) (n=14,885). Of 268 SNPs reaching P <5×10−4 for CAC in CRIC, 28 SNPs in 23 loci had nominal support (P <0.05 and in same direction) for CAC in PennCAC or AFCS. Besides chr9p21 and COL4A1, known loci for CHD, these included SNPs having reported GWAS association with hypertension (e.g., ATP2B1). In PROMIS, four of the 23 suggestive CAC loci (chr9p21, COL4A1, ATP2B1 and ABCA4) had significant associations with MI consistent with their direction of effect on CAC. We identified several loci associated with CAC in CKD that also relate to MI in a general population sample. CKD imparts a high risk of CHD and may provide a useful setting for discovery of novel CHD genes and pathways.
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影响因子：
5.8
作者：
Johnson, Andrew D.;Handsaker, Robert E.;de Bakker, Paul I. W.
通讯作者：
de Bakker, Paul I. W.
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
全基因组关联研究，用于冠状动脉钙化，随访心肌梗塞。
影响因子：
37.8
作者：
O'Donnell CJ;Kavousi M;Smith AV;Kardia SL;Feitosa MF;Hwang SJ;Sun YV;Province MA;Aspelund T;Dehghan A;Hoffmann U;Bielak LF;Zhang Q;Eiriksdottir G;van Duijn CM;Fox CS;de Andrade M;Kraja AT;Sigurdsson S;Elias-Smale SE;Murabito JM;Launer LJ;van der Lugt A;Kathiresan S;CARDIoGRAM Consortium;Krestin GP;Herrington DM;Howard TD;Liu Y;Post W;Mitchell BD;O'Connell JR;Shen H;Shuldiner AR;Altshuler D;Elosua R;Salomaa V;Schwartz SM;Siscovick DS;Voight BF;Bis JC;Glazer NL;Psaty BM;Boerwinkle E;Heiss G;Blankenberg S;Zeller T;Wild PS;Schnabel RB;Schillert A;Ziegler A;Münzel TF;White CC;Rotter JI;Nalls M;Oudkerk M;Johnson AD;Newman AB;Uitterlinden AG;Massaro JM;Cunningham J;Harris TB;Hofman A;Peyser PA;Borecki IB;Cupples LA;Gudnason V;Witteman JC
通讯作者：
Witteman JC
影响因子：
30.8
作者：
Kathiresan S;Willer CJ;Peloso GM;Demissie S;Musunuru K;Schadt EE;Kaplan L;Bennett D;Li Y;Tanaka T;Voight BF;Bonnycastle LL;Jackson AU;Crawford G;Surti A;Guiducci C;Burtt NP;Parish S;Clarke R;Zelenika D;Kubalanza KA;Morken MA;Scott LJ;Stringham HM;Galan P;Swift AJ;Kuusisto J;Bergman RN;Sundvall J;Laakso M;Ferrucci L;Scheet P;Sanna S;Uda M;Yang Q;Lunetta KL;Dupuis J;de Bakker PI;O'Donnell CJ;Chambers JC;Kooner JS;Hercberg S;Meneton P;Lakatta EG;Scuteri A;Schlessinger D;Tuomilehto J;Collins FS;Groop L;Altshuler D;Collins R;Lathrop GM;Melander O;Salomaa V;Peltonen L;Orho-Melander M;Ordovas JM;Boehnke M;Abecasis GR;Mohlke KL;Cupples LA
通讯作者：
Cupples LA
影响因子：
5.3
作者：
Coylewright, Megan;Rice, Kenneth;Post, Wendy S.
通讯作者：
Post, Wendy S.