Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety.
Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety.
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DOI：
10.1038/npp.2008.113
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发表时间：
2009-01
影响因子：
7.6
通讯作者：
Fox, Nathan A.
中科院分区：
文献类型：
--
作者：
Pine, Daniel S.;Helfinstein, Sarah M.;Bar-Haim, Yair;Nelson, Eric;Fox, Nathan A.
大脑发育的改变可能会导致慢性精神障碍。针对这种慢性疾病的儿童早期表现的新疗法可能提供独特的治疗机会。然而，开发和提供新治疗的尝试面临许多挑战。儿科焦虑症的工作说明了固有的挑战以及治疗进展的不寻常的机会。本综述总结了三个方面的转化研究儿童焦虑症的工作通知努力开发新的干预措施。首先，综述从基础神经科学和临床角度总结了焦虑的发展概念化的数据。本摘要结合了两种最好的治疗方法，认知行为疗法和选择性5-羟色胺再摄取抑制剂的讨论。其次，综述总结了对威胁的注意偏向的工作，考虑到新的治疗方法和神经回路功能发育的转化研究的影响。这说明了临床发现为基础系统神经科学研究提供信息的方式。最后，综述总结了恐惧学习的基础科学工作，如恐惧条件反射，巩固和灭绝范式的研究。本摘要最后描述了潜在的新治疗方法，说明了基础神经科学告知治疗方法的方式。
Alterations in brain development may contribute to chronic mental disorders. Novel treatments targeted toward the early-childhood manifestations of such chronic disorders may provide unique therapeutic opportunities. However, attempts to develop and deliver novel treatments face many challenges. Work on pediatric anxiety disorders illustrates both the inherent challenges as well as the unusual opportunities for therapeutic advances. The present review summarizes three aspects of translational research on pediatric anxiety disorders as the work informs efforts to develop novel interventions. First, the review summarizes data on developmental conceptualizations of anxiety from both basic neuroscience and clinical perspectives. This summary is integrated with a discussion of the two best-established treatments, cognitive behavioral therapy and selective serotonin reuptake inhibitors. Second, the review summarizes work on attention bias to threat, considering implications for both novel treatments and translational research on neural circuitry functional development. This illustrates the manner in which clinical findings inform basic systems neuroscience research. Finally, the review summarizes work in basic science on fear learning, as studied in fear conditioning, consolidation, and extinction paradigms. This summary ends by describing potential novel treatments, illustrating the manner in which basic neuroscience informs therapeutics.
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影响因子：
10.6
作者：
Carola, Valeria;Frazzetto, Giovanni;Gross, Cornelius
通讯作者：
Gross, Cornelius
影响因子：
--
作者：
Beesdo, Katja;Bittner, Antje;Wittchen, Hans-Ulrich
通讯作者：
Wittchen, Hans-Ulrich
影响因子：
5.3
作者：
Fischer, A;Sananbenesi, F;Radulovic, J
通讯作者：
Radulovic, J
DOI：
10.1196/annals.1364.056
发表时间：
2006-01-01
期刊：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS
影响因子：
--
作者：
Debiec, Jacek;LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.
影响因子：
4.1
作者：
Eldar, Sharon;Ricon, Tsameret;Bar-Haim, Yair
通讯作者：
Bar-Haim, Yair