Pre-stress performance in an instrumental training predicts post-stress behavioral alterations in chronically stressed rats.
Pre-stress performance in an instrumental training predicts post-stress behavioral alterations in chronically stressed rats.
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工具训练中的压力性能预测了长期压力大鼠的应激后行为改变。
DOI：
10.3389/fnbeh.2015.00119
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发表时间：
2015
影响因子：
3
通讯作者：
Toda S
中科院分区：
文献类型：
--
作者：
Iguchi Y;Kosugi S;Lin Z;Nishikawa H;Minabe Y;Toda S
压力是重性抑郁症（MDD）发展的主要因素，但很少有研究基于压力前的行为和认知特征来评估个体风险。为了解决这个问题，我们采用了食欲工具杠杆按压与渐进比例（PR）的时间表，以评估这些性状在实验幼稚的Sprague-Dawley大鼠。根据层次聚类分析确定的4个不同特征，将动物分为相应的4个亚组（低动机、快速学习者、缓慢学习者和过度动机），并暴露于慢性不可预测的应激（CUS），然后监测其应激后反应4周。这四个亚组代表了CUS后以下不同的行为表型：低动机亚组表现出体重减轻和PR表现的后期发展矛盾增强，这可能与人类MDD中的不适当决策有关。快速学习者亚组表现出短暂的动机丧失和血清皮质酮（CORT）对重复压力的反应。慢学习者亚组表现出对去动机的抵抗和对急性应激的CORT反应的抑制。最后，超动机亚组表现出抵抗体重减轻，习惯性CORT反应的急性压力，和持久的动机。总的来说，我们确定了在每个亚组中，压力前特征在工具训练和压力后表型的表现之间的因果关系。此外，大鼠中的许多α诱导表型与人类MDD的代表性症状相对应或具有推定的关系。我们的结论是，压力的后果可能是可预测的压力暴露前，通过确定应激前的行为或认知特征的每个人在大鼠。
Stress is a major factor in the development of major depressive disorder (MDD), but few studies have assessed individual risk based on pre-stress behavioral and cognitive traits. To address this issue, we employed appetitive instrumental lever pressing with a progressive ratio (PR) schedule to assess these traits in experimentally naïve Sprague-Dawley rats. Based on four distinct traits that were identified by hierarchical cluster analysis, the animals were classified into the corresponding four subgroups (Low Motivation, Quick Learner, Slow Learner, and Hypermotivation), and exposed to chronic unpredictable stress (CUS) before monitoring their post-stress responses for 4 weeks. The four subgroups represented the following distinct behavioral phenotypes after CUS: the Low Motivation subgroup demonstrated weight loss and a late-developing paradoxical enhancement in PR performance that may be related to inappropriate decision-making in human MDD. The Quick Learner subgroup exhibited a transient loss of motivation and the habituation of serum corticosterone (CORT) response to repeated stress. The Slow Learner subgroup displayed resistance to demotivation and a suppressed CORT response to acute stress. Finally, the Hypermotivation subgroup exhibited resistance to weight loss, habituated CORT response to an acute stress, and a long-lasting amotivation. Overall, we identified causal relationships between pre-stress traits in the performance of the instrumental training and post-stress phenotypes in each subgroup. In addition, many of the CUS-induced phenotypes in rats corresponded to or had putative relationships with representative symptoms in human MDD. We concluded that the consequences of stress may be predictable before stress exposure by determining the pre-stress behavioral or cognitive traits of each individual in rats.
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影响因子：
4.3
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