Distinct brain activity in processing negative pictures of animals and objects - the role of human contexts.

Distinct brain activity in processing negative pictures of animals and objects - the role of human contexts.
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DOI:
10.1016/j.neuroimage.2013.09.064
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发表时间:
2014-01-01
期刊:
影响因子:
5.7
通讯作者:
Yang J
Yang J
中科院分区:
医学1区
文献类型:
--
作者:
Cao Z;Zhao Y;Tan T;Chen G;Ning X;Zhan L;Yang J

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先前的研究表明,杏仁核不仅在处理生命实体方面很重要,而且在处理社会信息方面也很重要。类别和社会背景的因素在多大程度上相互作用,以调节杏仁核和皮质区域的活动,这一点还有待确定。在这项研究中,图片描绘动物和无生命的物体在消极和中性水平。这些照片的背景不同,它们是否包括人/人的部分。图片的效价、唤醒、熟悉度和复杂度等因素被控制在不同的类别中。结果表明,杏仁核的活动受到类别和背景信息的调制。在非人类背景条件下,杏仁核对动物的反应比对物体的反应更大。相比之下,在人类情境条件下,杏仁核对消极物体的反应比动物强。除了与物体动作相关的皮层区域外,功能和有效连接分析表明,在人类情境条件下,前额叶皮层与杏仁核的相互作用更多地针对负面物体(与动物相比),通过前额叶皮层对杏仁核的自上而下的调制。这些结果强调了类别和人类环境对调节情绪处理中大脑活动的影响。
Previous studies have shown that the amygdala is important in processing not only animate entities but also social information. It remains to be determined to what extent the factors of category and social context interact to modulate the activities of the amygdala and cortical regions. In this study, pictures depicting animals and inanimate objects in negative and neutral levels were presented. The contexts of the pictures differed in whether they included human/human parts. The factors of valence, arousal, familiarity and complexity of pictures were controlled across categories. The results showed that the amygdala activity was modulated by category and contextual information. Under the nonhuman context condition, the amygdala responded more to animals than objects for both negative and neutral pictures. In contrast, under the human context condition, the amygdala showed stronger activity for negative objects than animals. In addition to cortical regions related to object action, functional and effective connectivity analyses showed that the anterior prefrontal cortex interacted with the amygdala more for negative objects (vs. animals) in the human context condition, by a top-down modulation of the anterior prefrontal cortex to the amygdala. These results highlighted the effects of category and human contexts on modulating brain activity in emotional processing.
人类右侧杏仁核对动物的特定类别反应。
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