The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.
The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.
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DOI：
10.1111/j.1600-6143.2012.04180.x
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Najafian N
中科院分区：
文献类型：
--
作者：
Magee CN;Boenisch O;Najafian N
共刺激分子是一组异质性的细胞表面分子，其作用是放大或抵消T细胞受体（TCR）在与抗原/主要组织相容性复合体（MHC）相互作用后提供给T细胞的初始激活信号，从而影响T细胞的分化和命运。虽然以前认为共刺激对于T细胞在发育的各个阶段的激活是必不可少的，但现在知道，对共刺激的需求以及所涉及的共刺激分子，根据T细胞分化的阶段而变化。影响T细胞命运的能力是移植领域最重要的兴趣，因为我们寻求抑制有害的同种免疫反应的治疗选择，同时促进同种异体移植物的耐受性。与许多免疫机制一样，某些共刺激分子之间存在一定程度的功能重叠，而一些共刺激分子尽管具有共同的配体，但对不同的T细胞亚群具有截然相反的作用。当考虑将这些分子作为移植的治疗靶点时，这是一个关键点，因为阻断共刺激途径虽然本身是可取的，但可能会阻止必要的调节共抑制分子的结扎。本文综述了与移植相关的辅助性T细胞谱系和参与其分化的共刺激分子。
Co-stimulatory molecules are a heterogenous group of cell surface molecules that act to amplify or counteract the initial activating signals provided to T cells from the T cell receptor (TCR) following its interaction with an antigen/major histocompatibility complex (MHC), thereby influencing T cell differentiation and fate. While co-stimulation was previously thought to be indispensable for T cell activation at all stages of development, it is now known that the requirements for co-stimulation, and co-stimulatory molecules involved, vary according to the stage of T cell differentiation. The ability to influence T cell fate is of paramount interest in the field of transplantation as we seek therapeutic options that inhibit detrimental alloimmune responses whilst simultaneously promoting allograft tolerance. As with many immune mechanisms, there is a degree of functional overlap between certain co-stimulatory molecules, while some have diametrically opposite effects on different T cell subsets despite sharing common ligands. This is a critical point when considering these molecules as therapeutic targets in transplantation, as blockade of a co-stimulatory pathway, while desirable in itself, may prevent the ligation of an essential regulatory co-inhibitory molecule. This review discusses the T helper cell lineages pertinent to transplantation and the co-stimulatory molecules involved in their differentiation.
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DOI：
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发表时间：
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影响因子：
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发表时间：
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Najafian N
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10.4049/jimmunol.182.1.379
发表时间：
2009-01-01
期刊：
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影响因子：
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作者：
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影响因子：
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