Gene-environment interactions in Parkinson's disease: the importance of animal modeling.
Gene-environment interactions in Parkinson's disease: the importance of animal modeling.
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DOI：
10.1038/clpt.2010.138
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发表时间：
2010-10
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
帕金森病（PD）是一种迟发性神经退行性疾病，最常见的是以“散发性”（特发性）形式发生，没有明确定义的遗传基础，只有模糊描述的发病机制。总之，PD的各种单基因形式（即，由单个基因突变引起的突变）占PD病例的少数，但为疾病机制提供了重要的见解。虽然人们普遍认为，散发性PD是由叠加在个体的复合遗传易感性上的终生环境暴露引起的，但这一假设尚未得到充分验证。本文综述了与PD相关的遗传和环境因素，并试图将这些因素纳入致病框架。我们认为，动物模型将变得越来越重要，试图阐明基因-环境相互作用，以确定致病机制，并提供一个平台，有针对性的治疗干预措施的测试。
Parkinson's disease (PD), a late-onset neurodegenerative disorder, occurs most commonly in a “sporadic” (idiopathic) form, without a clearly defined genetic basis and only a vaguely delineated pathogenesis. Together, the various monogenic forms of PD (i.e., those arising from mutations in single genes) account for a minority of PD cases but have provided crucial insights into disease mechanisms. Although it is commonly believed that sporadic PD is caused by a lifetime of environmental exposures that are superimposed on an individual's composite genetic susceptibility, this hypothesis has not been tested adequately. This article reviews genetic and environmental factors that have been associated with PD and attempts to put these into a pathogenic framework. We argue that animal modeling will become increasingly important in attempting to elucidate gene–environment interactions, to define pathogenic mechanisms, and to provide a platform for testing of targeted therapeutic interventions.
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影响因子：
25
作者：
Li, Yanping;Liu, Wencheng;Oo, Tinmarla F.;Wang, Lei;Tang, Yi;Jackson-Lewis, Vernice;Zhou, Chun;Geghman, Kindiya;Bogdanov, Mikhail;Przedborski, Serge;Beal, M. Flint;Burke, Robert E.;Li, Chenjian
通讯作者：
Li, Chenjian
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
DOI：
10.1073/pnas.0705363105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Haque, M. Emdadul;Thomas, Kelly J.;Park, David S.
通讯作者：
Park, David S.
影响因子：
4.7
作者：
Casarejos, MJ;Menéndez, J;Mena, MA
通讯作者：
Mena, MA
DOI：
10.1083/jcb.200809125
发表时间：
2008-12-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Narendra D;Tanaka A;Suen DF;Youle RJ
通讯作者：
Youle RJ