Long COVID in a prospective cohort of home-isolated patients.
Long COVID in a prospective cohort of home-isolated patients.
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DOI：
10.1038/s41591-021-01433-3
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发表时间：
2021-09
期刊：
影响因子：
82.9
通讯作者：
Langeland N
中科院分区：
文献类型：
--
作者：
Blomberg B;Mohn KG;Brokstad KA;Zhou F;Linchausen DW;Hansen BA;Lartey S;Onyango TB;Kuwelker K;Sævik M;Bartsch H;Tøndel C;Kittang BR;Bergen COVID-19 Research Group;Cox RJ;Langeland N
2019冠状病毒病（COVID-19）后的长期并发症在住院患者中很常见，但轻度病例的症状谱需要进一步调查。我们对312名患者进行了一项前瞻性队列研究的长期随访，其中247人在家隔离，65人住院，占挪威第一波大流行期间卑尔根总病例的82%。在6个月时，所有患者中有61%（189/312）出现持续症状，这些症状与初始疾病的严重程度、恢复期抗体滴度增加和既存慢性肺病独立相关。我们发现，52%（32/61）的16-30岁的家庭隔离年轻人在6个月时出现症状，包括味觉和/或嗅觉丧失（28%，17/61），疲劳（21%，13/61），呼吸困难（13%，8/61），注意力受损（13%，8/61）和记忆问题（11%，7/61）。我们的研究发现，患有轻度COVID-19的年轻、居家隔离的成年人有长期呼吸困难和认知症状的风险，这突出了感染控制措施（如疫苗接种）的重要性。对挪威卑尔根的SARS-CoV-2感染患者前瞻性入组队列的分析显示，尽管患者相对年轻且仅具有轻度至中度急性COVID-19症状，但在6个月时经历长期COVID症状的患者比例很高。
Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients—247 home-isolated and 65 hospitalized—comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16–30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination. Analysis of a prospectively enrolled cohort of patients with SARS-CoV-2 infections in Bergen, Norway, reveals a high proportion of patients who experienced long COVID symptoms at 6 months, despite being relatively young and having only mild to moderate acute COVID-19 symptoms.
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DOI：
10.1016/j.lanepe.2020.100014
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Kuwelker K;Zhou F;Blomberg B;Lartey S;Brokstad KA;Trieu MC;Bansal A;Madsen A;Krammer F;Mohn KG;Tøndel C;Linchausen DW;Cox RJ;Langeland N;Bergen COVID-19 research group
通讯作者：
Bergen COVID-19 research group
影响因子：
13.8
作者：
Bellan M;Soddu D;Balbo PE;Baricich A;Zeppegno P;Avanzi GC;Baldon G;Bartolomei G;Battaglia M;Battistini S;Binda V;Borg M;Cantaluppi V;Castello LM;Clivati E;Cisari C;Costanzo M;Croce A;Cuneo D;De Benedittis C;De Vecchi S;Feggi A;Gai M;Gambaro E;Gattoni E;Gramaglia C;Grisafi L;Guerriero C;Hayden E;Jona A;Invernizzi M;Lorenzini L;Loreti L;Martelli M;Marzullo P;Matino E;Panero A;Parachini E;Patrucco F;Patti G;Pirovano A;Prosperini P;Quaglino R;Rigamonti C;Sainaghi PP;Vecchi C;Zecca E;Pirisi M
通讯作者：
Pirisi M
影响因子：
5.9
作者：
Buchwald, DS;Rea, TD;Ashley, RL
通讯作者：
Ashley, RL
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
4.7
作者：
Loge, JH;Ekeberg, O;Kaasa, S
通讯作者：
Kaasa, S