Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study.
Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study.
复制标题
DOI：
10.1016/j.lanepe.2020.100014
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Bergen COVID-19 research group
中科院分区：
文献类型：
--
作者：
Kuwelker K;Zhou F;Blomberg B;Lartey S;Brokstad KA;Trieu MC;Bansal A;Madsen A;Krammer F;Mohn KG;Tøndel C;Linchausen DW;Cox RJ;Langeland N;Bergen COVID-19 research group
家庭研究反映了SARS-CoV-2在免疫幼稚人群中自然传播，而控制传播的预防措施有限。我们假设血清阳性提供比RT-PCR更准确的家庭发病率。在这里，我们调查了年龄在家庭传播动态中的重要性。2020年2月28日至4月4日，我们在挪威卑尔根的一项病例确定研究中招募了112个家庭（291名参与者），收集了指数患者和家庭成员的人口统计学和临床数据。在指标患者鼻咽检测后6-8周收集的血清中检测sars - cov -2特异性抗体，以确定家庭发作率。血清学评估的总发作率为45% (95% CI 38-53)，当还包括血清RT-PCR阳性时为47%。血清学鉴定出比RT-PCR更多的感染家庭成员。儿童（48%）和年轻人（42%）的发病率同样高。无症状家庭成员的发病率为16%，RT-PCR阴性接触者的发病率为42%。老年人的抗体滴度高于年轻人。急性期发热（aOR 3.31 [95% CI 1.52 ~ 7.24]; p = 0.003）或呼吸困难（aOR 2.25 [95% CI 1.80 ~ 4.62]; p = 0.027）时，家庭传播风险较高。血清学分析提供比RT-PCR更敏感和可靠的家庭发病率估计。儿童和年轻人一样容易受到感染。RT-PCR阴性或无症状不足以排除家庭成员感染。Helse Vest (F-11628)， Trond Mohn基金会（TMS2020TMT05）。
Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission. We hypothesise that seropositivity provides more accurate household attack rates than RT-PCR. Here, we investigated the importance of age in household transmission dynamics. We enroled 112 households (291 participants) in a case-ascertained study in Bergen, Norway from 28th February to 4th April 2020, collecting demographic and clinical data from index patients and household members. SARS-CoV-2-specific antibodies were measured in sera collected 6–8 weeks after index patient nasopharyngeal testing to define household attack rates. The overall attack rate was 45% (95% CI 38–53) assessed by serology, and 47% when also including seronegative RT-PCR positives. Serology identified a higher number of infected household members than RT-PCR. Attack rates were equally high in children (48%) and young adults (42%). The attack rate was 16% in asymptomatic household members and 42% in RT-PCR negative contacts. Older adults had higher antibody titres than younger adults. The risk of household transmission was higher when the index patient had fever (aOR 3.31 [95% CI 1.52–7.24]; p = 0.003) or dyspnoea (aOR 2.25 [95% CI 1.80–4.62]; p = 0.027) during acute illness. Serological assays provide more sensitive and robust estimates of household attack rates than RT-PCR. Children are equally susceptible to infection as young adults. Negative RT-PCR or lack of symptoms are not sufficient to rule out infection in household members. Helse Vest (F-11628), Trond Mohn Foundation (TMS2020TMT05).
登录
查看更多内容
DOI：
10.3138/jammi-2020-0030
发表时间：
2020-12-01
期刊：
Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada
影响因子：
--
作者：
Byambasuren, Oyungerel;Cardona, Magnolia;Glasziou, Paul
通讯作者：
Glasziou, Paul
影响因子：
56.3
作者：
Boehmer, Merle M.;Buchholz, Udo;Zapf, Andreas
通讯作者：
Zapf, Andreas
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
5.6
作者：
Zhang, Jin;Zhang, Xiaoming;Zheng, Rui
通讯作者：
Zheng, Rui
影响因子：
11.8
作者：
Rosenberg, Eli S.;Dufort, Elizabeth M.;Zucker, Howard A.
通讯作者：
Zucker, Howard A.