Genomic imprinting: recognition and marking of imprinted loci.
Genomic imprinting: recognition and marking of imprinted loci.
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DOI：
10.1016/j.gde.2011.12.001
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发表时间：
2012-04
影响因子：
4
通讯作者：
Bartolomei, Marisa S.
中科院分区：
文献类型：
--
作者：
Abramowitz, Lara K.;Bartolomei, Marisa S.
基因组印记是一种表观遗传过程，导致哺乳动物基因组中一个基因子集的单等位基因的起源特异性表达。在配子发生过程中，当基因组处于不同的区室中时，亲本等位基因通过DNA甲基化进行差异标记。甲基化机制如何识别和差异修饰生殖细胞中的这些印记区域仍然是该领域的关键问题。虽然研究的重点是确定一个序列签名，单独可以区分印记区域从其余的基因组，最近的报告不支持这样的假设。相反，越来越清楚的是，诸如转录、组蛋白修饰和高阶染色质的特征单独或组合地用于建立亲本印记。
Genomic imprinting is an epigenetic process resulting in the monoallelic parent-of-origin-specific expression of a subset of genes in the mammalian genome. The parental alleles are differentially marked by DNA methylation during gametogenesis when the genomes are in separate compartments. How methylation machinery recognizes and differentially modifies these imprinted regions in germ cells remains a key question in the field. While studies have focused on determining a sequence signature that alone could distinguish imprinted regions from the rest of the genome, recent reports do not support such a hypothesis. Rather, it is becoming clear that features such as transcription, histone modifications and higher order chromatin are employed either individually or in combination to set up parental imprints.
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影响因子：
30.8
作者：
Engel, N;West, AG;Bartolomei, MS
通讯作者：
Bartolomei, MS
影响因子：
5.3
作者：
Lin, Shu;Ferguson-Smith, Anne C.;Bartolomei, Marisa S.
通讯作者：
Bartolomei, Marisa S.
影响因子：
4.5
作者：
Frost JM;Moore GE
通讯作者：
Moore GE
影响因子：
3.5
作者：
Kato, Yuzuru;Kaneda, Masahiro;Sasaki, Hiroyuki
通讯作者：
Sasaki, Hiroyuki
影响因子：
56.9
作者：
Bourc'his, D;Xu, GL;Bestor, TH
通讯作者：
Bestor, TH