The importance of imprinting in the human placenta.
The importance of imprinting in the human placenta.
复制标题
DOI：
10.1371/journal.pgen.1001015
复制
发表时间：
2010-07-01
期刊：
影响因子：
4.5
通讯作者：
Moore GE
中科院分区：
文献类型：
--
作者：
Frost JM;Moore GE
作为一个研究领域，基因组印迹在过去20年中迅速发展，在小鼠中已知的印迹基因约为100个，在人类中约为50个。基因的印记表达可能是短暂的和高度组织特异性的，并且可能存在数百种其他尚未发现的印记转录本。胎盘是哺乳动物器官中值得注意的印记基因的高和多产的表达。本文综述了胎盘的发育过程，并重点介绍了胎盘中印记的功能。印记是一种潜在的平衡亲本资源分配的机制，在植物生长中起着重要的作用。胎盘作为母亲和胎儿之间的界面，对产前生长控制至关重要。多年来，已证明受亲本等位基因表达偏倚影响的基因表达对于胎盘的正常发育和生理是必不可少的。在这篇综述中，我们还讨论了缺乏小鼠和人类之间的印记，其印记的表达往往是胎盘特异性的基因的保护的意义。最后，我们说明了印迹在出生后的人在几个人类印迹疾病方面的重要性，考虑到大脑作为出生后印迹基因表达的关键器官。
As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes may be transient and highly tissue-specific, and there are potentially hundreds of other, as yet undiscovered, imprinted transcripts. The placenta is notable amongst mammalian organs for its high and prolific expression of imprinted genes. This review discusses the development of the human placenta and focuses on the function of imprinting in this organ. Imprinting is potentially a mechanism to balance parental resource allocation and it plays an important role in growth. The placenta, as the interface between mother and fetus, is central to prenatal growth control. The expression of genes subject to parental allelic expression bias has, over the years, been shown to be essential for the normal development and physiology of the placenta. In this review we also discuss the significance of genes that lack conservation of imprinting between mice and humans, genes whose imprinted expression is often placental-specific. Finally, we illustrate the importance of imprinting in the postnatal human in terms of several human imprinting disorders, with consideration of the brain as a key organ for imprinted gene expression after birth.
登录
查看更多内容
影响因子：
3.8
作者：
Enders, A. C.
通讯作者：
Enders, A. C.
DOI：
10.1073/pnas.1532175100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Charalambous, M;Smith, FM;Ward, A
通讯作者：
Ward, A
影响因子：
64.8
作者：
BARTOLOMEI, MS;ZEMEL, S;TILGHMAN, SM
通讯作者：
TILGHMAN, SM
影响因子：
3.7
作者：
Ding, Feng;Li, Hong Hua;Zhang, Shengwen;Solomon, Nicola M.;Camper, Sally A.;Cohen, Pinchas;Francke, Uta
通讯作者：
Francke, Uta
影响因子：
64.8
作者：
CATTANACH, BM;KIRK, M
通讯作者：
KIRK, M