Plasma Ghrelin Modulation in Gastric Band Operation and Sleeve Gastrectomy
Plasma Ghrelin Modulation in Gastric Band Operation and Sleeve Gastrectomy
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胃束带手术和袖状胃切除术中的血浆生长素释放肽调节
DOI：
10.1007/s11695-008-9688-3
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发表时间：
2009
期刊：
影响因子：
2.9
通讯作者：
Jingang Liu
中科院分区：
文献类型：
--
作者：
Yong Wang;Jingang Liu
背景胃束带术和袖状胃切除术是近年来流行的减肥手术。本研究的目的是探讨胃束带术和袖状胃切除术对肥胖大鼠体重指数、脂肪量、血浆ghrelin水平、下丘脑ghrelin受体表达的影响。和下丘脑生长激素促分泌素受体1a（GHS-R1 a）蛋白表达。与之相比，2005年在我院接受腹腔镜可调节胃束带术（LAGB）和腹腔镜袖状胃切除术（LSG）的患者数据也进行了总结。袖带组血浆ghrelin浓度为对照组的0.4倍，胃束带组约为对照组的2倍。袖带组下丘脑GHS-R1 a蛋白表达是对照组的1.5倍，而胃束带组仅为对照组的0.9倍。临床数据显示，LSG组患者在2年随访中体重减轻了60%。结论LAGB和LSG均能降低患者的超重体重和脂肪量。血浆ghrelin水平随着LSG操作而下调，但随着LAGB操作而上调。袖状胃切除术后下丘脑GHS-R1 a表达升高
BackgroundGastric band operation and sleeve gastrectomy are increasingly popular bariatric surgeries for weight loss. The purpose of this study is to investigate the changes in plasma ghrelin levels and hypothalamic ghrelin receptor expression with weight loss achieved through these surgeries.MethodsTwenty-four high fat diet-induced obese rats were used to investigate the effects of gastric band and sleeve operation on Body Mass Index, fat mass, plasma ghrelin levels, and hypothalamic growth hormone secretagogue receptor 1a (GHS-R 1a) protein expression in hypothalamus. In comparison, data of patients who received laparoscopic adjustable gastric banding (LAGB) and laparoscopic sleeve gastrectomy (LSG) in our hospital in 2005 were also summarized.ResultsBody weights and fat mass decreased significantly in rats that received operation. Plasma ghrelin concentrations in the sleeve group were 0.4-fold of control rats and about 2-fold of control in the gastric band group. GHS-R1a protein expression in hypothalamus was 1.5-fold in the sleeve group compared with control group, while it was only 0.9-fold in the gastric band group. Clinical data showed that patients in the LSG group lost 60% excess body weights in 2 years follow-up. After operation, fasting plasma ghrelin concentrations in LAGB was significantly higher than the LSG group.ConclusionBoth LAGB and LSG can decrease patients’ excess body weights and fat mass. Plasma ghrelin levels are down-regulated with LSG operation but up-regulated with LAGB operation. Hypothalamic GHS-R1a expression is elevated in sleeve gastrectomy.
肥胖 Zucker 大鼠的肾损伤：肾小球血流动力学改变和依那普利的影响。
DOI：
10.1152/ajprenal.1992.263.3.f496
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Schmitz,PG;O'Donnell,MP;Kasiske,BL;Katz,SA;Keane,WF
通讯作者：
Keane,WF