Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction.
Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction.
复制标题
通过区域质子磁共振波谱法检测脑梗死患者的脑乳酸。
作者：
J. B. Sprenkel;P. Luyten;P. C. V. Rijen;C. Tulleken;J. A. D. Hollander
水抑制图像引导局部质子磁共振波谱在一个59岁的妇女进行了两个主要的脑梗死。在梗塞灶、梗塞灶之间的区域和健康半球中测量光谱。根据快速T2加权图像选择感兴趣的体积。使用1331-2662 Hahn自旋回波序列来抑制通过空间分辨光谱学或受激回波选择的8 cm 3体积中的水。在5分钟的累积时间内获得光谱。应用光谱编辑将乳酸盐的共振与其他物质的共振分离。我们的研究结果表明，6个月后梗死内的乳酸浓度没有增加;然而，在1.6 ppm处观察到共振，这被分配给脂肪酸。脑特异性化合物的峰强度降低。临床症状发作后6个月（搭桥手术时），在两次梗死之间的区域观察到乳酸浓度比正常值增加了5倍。搭桥手术后四个月，该区域的乳酸浓度降至正常值的两倍。我们推测乳酸是可逆或即将发生的脑损伤的标志物。
Water-suppressed image-guided localized proton magnetic resonance spectroscopy was performed in a 59-year-old woman with two major brain infarcts. Spectra were measured in the infarcts, in an area between the infarcts, and in the healthy hemisphere. The volumes of interest were selected on the basis of a fast T2-weighted image. A 1331-2662 Hahn spin-echo sequence was used to suppress the water in the 8-cm3 volume that was selected by means of spatially resolved spectroscopy or stimulated echoes. The spectra were obtained in 5 minutes' accumulation time. Spectral editing was applied to separate the resonance of lactate from that of other substances. Our results show no increase of lactate concentration within the infarcts after 6 months; however, a resonance was observed at 1.6 ppm, which is assigned to fatty acids. Peak intensities of brain-specific compounds were decreased. Six months after the onset of clinical symptoms (at the time of bypass surgery), a fivefold increase in lactate concentration compared with normal values was observed in the area between the two infarcts. Four months after bypass surgery, the lactate concentration in this area had decreased to only twice normal. We speculate that lactate is a marker of reversible or impending brain damage.
DOI：
10.1073/pnas.80.16.4945
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
BEHAR, KL;DENHOLLANDER, JA;PRICHARD, JW
通讯作者：
PRICHARD, JW