Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency virus type 1 drug resistance.
Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency virus type 1 drug resistance.
复制标题
不同系统对抗逆转录病毒治疗结果的可变预测，用于解释基因型人类免疫缺陷病毒 1 型耐药性。
DOI：
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发表时间：
2003
影响因子：
6.4
通讯作者：
A. Antinori
中科院分区：
文献类型：
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作者：
A. De Luca;A. Cingolani;S. Di Giambenedetto;M. Trotta;F. Baldini;M. Rizzo;A. Bertoli;G. Liuzzi;P. Narciso;R. Murri;A. Ammassari;C. Perno;A. Antinori
为了确定现有专家系统对基因型人类免疫缺陷病毒 (HIV) 1 型耐药性解释的变异性及其临床意义，对 261 名开始挽救治疗的有效抗逆转录病毒治疗方案无效的受试者进行了评估。根据 11 种解释系统，检查了挽救方案的基因型易感性评分 (GSS) 与 6 个月的 HIV RNA 结果之间的关联。由不同的解释系统确定，GSS 变化很大，并且在 6 个月时与 5 个系统（斯坦福 hivdb、GuideLines 3.0、Retrogram 1.4、HIVresistanceWeb 和圣保罗大学）的基线 HIV RNA 水平变化呈独立相关。大多数 GSS 预测了含有司他夫定、拉米夫定、依非韦伦或茚地那韦的治疗方案中的病毒学反应。选定的系统预测了含有去羟肌苷、阿巴卡韦或奈非那韦的治疗方案的反应，但没有系统预测加强蛋白酶抑制剂的结果。 GSS 能够比非依从性个体更好地预测依从性患者中 HIV RNA 水平的变化。解释可能会得到改进，并且知识应该在不同的专家系统中统一使用。
To determine the variability of genotypic human immunodeficiency virus (HIV) type 1 drug-resistance interpretation by available expert systems and its clinical implications, 261 subjects for whom a potent antiretroviral regimen was failing who were starting salvage therapy were evaluated. The association of the genotypic susceptibility score (GSS) of the salvage regimen, according to 11 interpretation systems, with HIV RNA outcomes for 6 months was examined. GSS was highly variable, as determined by the different interpretation systems, and showed independent correlation with changes from baseline HIV RNA levels at 6 months with 5 systems--Stanford hivdb, GuideLines 3.0, Retrogram 1.4, HIVresistanceWeb, and São Paulo University. Most GSSs predicted virologic response in regimens containing stavudine, lamivudine, efavirenz, or indinavir. Selected systems predicted response in regimens containing didanosine, abacavir, or nelfinavir, and no system predicted outcome of boosted protease inhibitors. GSSs predicted changes in HIV RNA levels better in adherent patients than in nonadherent individuals. Interpretation may be improved, and knowledge should be used uniformly throughout different expert systems.
齐多夫定耐药突变对齐多夫定-拉米夫定-利托那韦治疗的病毒学反应的影响：来自艾滋病临床试验组方案 315.ACTG 方案 315 团队的人类免疫缺陷病毒 1 型分离株的基因型分析。
DOI：
10.1086/315244
发表时间：
2000
期刊：
The Journal of infectious diseases.
影响因子：
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作者：
Kuritzkes,DR;Sevin,A;Young,B;Bakhtiari,M;Wu,H;StClair,M;Connick,E;Landay,A;Spritzler,J;Kessler,H;Lederman,MM
通讯作者：
Lederman,MM