Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team.
Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team.
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齐多夫定耐药突变对齐多夫定-拉米夫定-利托那韦治疗的病毒学反应的影响：来自艾滋病临床试验组方案 315.ACTG 方案 315 团队的人类免疫缺陷病毒 1 型分离株的基因型分析。
DOI：
10.1086/315244
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Lederman,MM
中科院分区：
文献类型：
--
作者：
Kuritzkes,DR;Sevin,A;Young,B;Bakhtiari,M;Wu,H;StClair,M;Connick,E;Landay,A;Spritzler,J;Kessler,H;Lederman,MM
基线耐药突变对齐多夫定、拉米夫定和利托那韦反应的影响在齐多夫定经验的人类免疫缺陷病毒1型（HIV-1）感染者中进行了评估。K70R突变的存在与基线时血浆HIV-1 RNA水平显著升高相关。然而，耐药突变的存在不影响5周药物洗脱期血浆HIV-1 RNA的增加，也不影响开始治疗后的第一阶段病毒衰变率，也不影响第48周血浆HIV-1 RNA水平<100拷贝/mL的可能性。蛋白酶密码子10、36和71的多态性与二期衰减率显著加快相关。尽管存在齐多夫定耐药突变，但血浆HIV-1 RNA的抑制表明，这些突变的存在并不妨碍对有效的3药方案治疗的持久反应。
The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associated with significantly higher plasma HIV-1 RNA levels at baseline. However, presence of resistance mutations did not affect the increase in plasma HIV-1 RNA during a 5-week drug washout, nor was there any effect on first-phase virus decay rates after initiation of therapy or on the probability of having plasma HIV-1 RNA levels <100 copies/mL at week 48. Polymorphisms at protease codons 10, 36, and 71 were associated with significantly faster second-phase decay rates. Suppression of plasma HIV-1 RNA despite presence of zidovudine resistance mutations implies that the presence of these mutations does not preclude a durable response to treatment with a potent 3-drug regimen.
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治疗前、治疗期间和治疗后从患者体内分离出的齐多夫定耐药性人类免疫缺陷病毒的发病率。
影响因子：
6.4
作者：
S. Land;Catherine H. McGavin;Ron Lucas;C. Birch
通讯作者：
C. Birch
影响因子：
158.5
作者：
Gulick, RM;Mellors, JW;Chodakewitz, JA
通讯作者：
Chodakewitz, JA
影响因子：
2
作者：
H. Wu;A. Ding;V. De Gruttola
通讯作者：
H. Wu;A. Ding;V. De Gruttola
影响因子：
6.4
作者：
Wu, HL;Kuritzkes, DR;Lederman, MM
通讯作者：
Lederman, MM
影响因子：
6.4
作者：
Lederman, MM;Connick, E;Kessler, H
通讯作者：
Kessler, H