Pathogenicity and Virulence of Legionella: Intracellular replication and host response.
Pathogenicity and Virulence of Legionella: Intracellular replication and host response.
复制标题
DOI：
10.1080/21505594.2021.1903199
复制
发表时间：
2021-12
期刊：
影响因子：
5.2
通讯作者：
Shames SR
中科院分区：
文献类型：
--
作者：
Chauhan D;Shames SR
军团菌属的细菌是阿米巴原虫的天然病原体，其可在人类中引起称为军团菌病的严重肺炎。人类疾病是由于吸入军团菌污染的气溶胶和随后的肺泡巨噬细胞内的细菌复制。军团菌对人类的致病性是由于与变形虫不同属的广泛共同进化而产生的。为了在细胞内复制，军团菌通过数百个Dot/Icm易位效应蛋白的协同作用产生一个称为含军团菌空泡（LCV）的复制允许区室。在这篇综述中，我们提出了一个集体概述军团菌的致病性，包括感染机制，分泌系统，和易位效应功能。我们还讨论了先天性和适应性免疫反应L。嗜肺军团菌，军团菌基因组多样性的影响和该领域的未来途径。
Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe pneumonia in humans called Legionnaires’ Disease. Human disease results from inhalation of Legionella-contaminated aerosols and subsequent bacterial replication within alveolar macrophages. Legionella pathogenicity in humans has resulted from extensive co-evolution with diverse genera of amoebae. To replicate intracellularly, Legionella generates a replication-permissive compartment called the Legionella-containing vacuole (LCV) through the concerted action of hundreds of Dot/Icm-translocated effector proteins. In this review, we present a collective overview of Legionella pathogenicity including infection mechanisms, secretion systems, and translocated effector function. We also discuss innate and adaptive immune responses to L. pneumophila, the implications of Legionella genome diversity and future avenues for the field.
登录
查看更多内容
影响因子：
16.6
作者：
Arasaki K;Mikami Y;Shames SR;Inoue H;Wakana Y;Tagaya M
通讯作者：
Tagaya M
影响因子：
--
作者：
ANAND, CM;SKINNER, AR;KURTZ, JB
通讯作者：
KURTZ, JB
影响因子：
3.6
作者：
Bardill, JP;Miller, JL;Vogel, JP
通讯作者：
Vogel, JP
影响因子：
3.6
作者：
Bachman, MA;Swanson, MS
通讯作者：
Swanson, MS
影响因子：
4.6
作者：
Borges V;Nunes A;Sampaio DA;Vieira L;Machado J;Simões MJ;Gonçalves P;Gomes JP
通讯作者：
Gomes JP