Clinical Relevance of Autoantibodies against Interleukin-2 in Patients with Systemic Lupus Erythematosus.
Clinical Relevance of Autoantibodies against Interleukin-2 in Patients with Systemic Lupus Erythematosus.
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系统性红斑狼疮患者抗白细胞介素 2 自身抗体的临床相关性
DOI：
10.4103/0366-6999.235114
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发表时间：
2018-07-05
影响因子：
6.1
通讯作者：
Li ZG
中科院分区：
文献类型：
--
作者：
Shao M;Sun XL;Sun H;He J;Zhang RJ;Zhang X;Li ZG
背景：据报道，系统性红斑狼疮 (SLE) 患者和接受 IL-2 治疗的患者血清抗白细胞介素 2 自身抗体（抗 IL-2 自身抗体）增加。本研究旨在探讨血清抗IL-2自身抗体的临床相关性以及低剂量IL-2治疗与血清抗IL-2自身抗体之间的相互作用。方法：从 152 名 SLE 患者和 100 名年龄和性别匹配的健康对照 (HC) 中采集血清样本。其中，75 名 SLE 患者接受了为期 10 周的随访，所有患者均接受皮质类固醇、抗疟药和/或免疫抑制剂治疗。 75 名 SLE 患者中有 46 名另外接受了低剂量 IL-2 治疗。在基线和第 10 周收集临床和实验室参数。通过酶联免疫吸附测定测定血清抗 IL-2 自身抗体。结果：与HCs相比，SLE患者血清抗IL-2自身抗体中位水平和阳性率较高（分别为32.58[23.63,45.23]任意单位[AU] vs. 37.54[27.88,60.74]AU，P = 0.006和5.0% vs. 18.4%，P = 0.002）。与无相应疾病的患者相比，脱发患者血清抗IL-2自身抗体升高（49.79 [36.06, 64.95] AU vs. 35.06 [25.40, 58.46] AU，P = 0.033），而狼疮性肾炎患者血清抗IL-2自身抗体降低（31.71 [22.60, 43.25] AU）与 44.15 [31.43, 68.52] AU，P = 0.001）。此外，血清抗IL-2自身抗体与血清IgA（r = 0.229，P = 0.005）、总IgG（r = 0.327，P < 0.001）和总IgM（r = 0.164，P = 0.050）呈正相关。外源性IL-2治疗与血清抗IL-2自身抗体没有显着相关。此外，低剂量IL-2治疗有反应者和无反应者之间的血清抗IL-2自身抗体没有发现显着差异。结论：SLE 患者血清抗 IL-2 自身抗体升高，且与疾病严重程度相关。外源性低剂量IL-2没有显着诱导抗IL-2自身抗体的产生。
Background: Increased serum autoantibodies against interleukin-2 (anti-IL-2 autoantibodies) were reported in patients with systemic lupus erythematosus (SLE) and in patients receiving IL-2 therapy. This study aimed to explore the clinical relevance of serum anti-IL-2 autoantibodies and the interactions between low-dose IL-2 therapy and serum anti-IL-2 autoantibodies. Methods: Serum samples were collected from 152 SLE patients and 100 age- and gender-matched healthy controls (HCs). Among them, 75 SLE patients were followed up for 10 weeks, and all of them were treated with corticosteroids, antimalarials, and/or immunosuppressants. Forty-six out of the 75 SLE patients received low-dose IL-2 therapy additionally. Clinical and laboratory parameters were collected at baseline and week 10. Serum anti-IL-2 autoantibodies were determined by enzyme-linked immunosorbent assay. Results: Compared with HCs, median levels and positive rates of serum anti-IL-2 autoantibodies were higher in SLE patients (32.58 [23.63, 45.23] arbitrary unit [AU] vs. 37.54 [27.88, 60.74] AU, P = 0.006, and 5.0% vs. 18.4%, P = 0.002, respectively). Compared to those without the corresponding disorders, serum anti-IL-2 autoantibody was increased in patients with alopecia (49.79 [36.06, 64.95] AU vs. 35.06 [25.40, 58.46] AU, P = 0.033), but it was decreased in those with lupus nephritis (31.71 [22.60, 43.25] AU vs. 44.15 [31.43, 68.52] AU, P = 0.001). Moreover, serum anti-IL-2 autoantibody was positively correlated with serum IgA (r = 0.229, P = 0.005), total IgG (r = 0.327, P < 0.001), and total IgM (r = 0.164, P = 0.050). Treatment with exogenous IL-2 was not significantly associated with serum anti-IL-2 autoantibody. In addition, no significant difference was found in serum anti-IL-2 autoantibody between responders and nonresponders to low-dose IL-2 therapy. Conclusions: Serum anti-IL-2 autoantibody was increased and associated with disease severity in SLE. Exogenous low-dose IL-2 did not significantly induce anti-IL-2 autoantibody production.
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影响因子：
4.7
作者：
Lokshin, Anna E.;Winans, Mathew;Gorelik, Elieser
通讯作者：
Gorelik, Elieser
影响因子：
27.4
作者：
von Spee-Mayer, Caroline;Siegert, Elise;Humrich, Jens Y.
通讯作者：
Humrich, Jens Y.
影响因子：
4.3
作者：
ISHIZAKA, S;TSUJII, T
通讯作者：
TSUJII, T
DOI：
10.1089/jir.1994.14.177
发表时间：
1994-08-01
期刊：
JOURNAL OF INTERFERON RESEARCH
影响因子：
--
作者：
ATZPODIEN, J;HANNINEN, EL;POLIWODA, H
通讯作者：
POLIWODA, H
中国汉族人群增殖诱导配体、精子发生相关8、血小板衍生生长因子受体α、POLB多态性与系统性红斑狼疮的关联研究
影响因子：
6.1
作者：
Li P;Li Y;Zhou AH;Chen S;Li J;Wen XT;Wu ZY;Li LB;Zhang FC;Li YZ
通讯作者：
Li YZ