GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness.
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness.
复制标题
腹侧视皮层中GABA水平随年龄增长而下降，并与神经特异性相关。
DOI：
10.1016/j.neurobiolaging.2021.02.013
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发表时间：
2021-06
影响因子：
4.2
通讯作者：
Polk TA
中科院分区：
文献类型：
--
作者：
Chamberlain JD;Gagnon H;Lalwani P;Cassady KE;Simmonite M;Seidler RD;Taylor SF;Weissman DH;Park DC;Polk TA
与年龄相关的神经去分化——衰老大脑中神经表征独特性的下降——与认知能力的年龄相关下降有关。但是为什么神经的独特性会随着年龄的增长而下降呢？基于先前对非人类灵长类动物的研究和最近对人类的研究，我们假设抑制性神经递质γ -氨基丁酸（GABA）随着年龄的增长而下降，并与老年人的神经去分化有关。为了验证这一假设，我们使用磁共振波谱（MRS）来测量GABA，并使用功能性磁共振成像（fMRI）来测量一组老年人和年轻人腹侧视觉皮层的神经独特性。与年轻人相比，老年人在腹侧视觉皮层中表现出较低的GABA水平和较不明显的面部和房屋激活模式。此外，老年人体内GABA的个体差异正预测神经独特性的个体差异。这些结果为以下观点提供了新的支持：与年龄相关的GABA减少有助于人类腹侧视觉皮层中神经独特性（即神经去分化）的年龄相关减少。
Age-related neural dedifferentiation – a decline in the distinctiveness of neural representations in the aging brain– has been associated with age-related declines in cognitive abilities. But why does neural distinctiveness decline with age? Based on prior work in non-human primates and more recent work in humans, we hypothesized that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) declines with age and is associated with neural dedifferentiation in older adults. To test this hypothesis, we used magnetic resonance spectroscopy (MRS) to measure GABA and functional MRI (fMRI) to measure neural distinctiveness in the ventral visual cortex in a set of older and younger participants. Relative to younger adults, older adults exhibited lower GABA levels and less distinct activation patterns for faces and houses in the ventral visual cortex. Furthermore, individual differences in GABA within older adults positively predicted individual differences in neural distinctiveness. These results provide novel support for the view that age-related reductions of GABA contribute to age-related reductions in neural distinctiveness (i.e., neural dedifferentiation) in the human ventral visual cortex.
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影响因子：
5.7
作者：
Cassady K;Gagnon H;Freiburger E;Lalwani P;Simmonite M;Park DC;Peltier SJ;Taylor SF;Weissman DH;Seidler RD;Polk TA
通讯作者：
Polk TA
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH
影响因子：
5.3
作者：
Hermans, Lize;Leunissen, Inge;Swinnen, Stephan P.
通讯作者：
Swinnen, Stephan P.
影响因子：
3.5
作者：
Liao, Chenghong;Han, Qian;Su, Bing
通讯作者：
Su, Bing
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John