Network segregation varies with neural distinctiveness in sensorimotor cortex.
Network segregation varies with neural distinctiveness in sensorimotor cortex.
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DOI：
10.1016/j.neuroimage.2020.116663
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发表时间：
2020-05-15
期刊：
影响因子：
5.7
通讯作者：
Polk TA
中科院分区：
文献类型：
--
作者：
Cassady K;Gagnon H;Freiburger E;Lalwani P;Simmonite M;Park DC;Peltier SJ;Taylor SF;Weissman DH;Seidler RD;Polk TA
正常的衰老与感觉运动功能的下降有关。以前的研究已经将年龄相关的行为下降与神经分化的减少联系起来（即，去分化），包括神经激活模式的独特性降低和大规模神经网络在休息时的隔离。然而，迄今为止还没有研究探讨这两种神经测量之间的关系，以及它们是否解释了行为的相同方面。为了研究这些问题，我们收集了一组老年人和年轻人的感觉运动行为测量，并估计了（a）感觉运动皮层神经表征的独特性和（B）相同参与者的感觉运动网络隔离。与之前的研究结果一致，感觉运动表征不太明显，感觉运动静息状态网络在老年人中的隔离程度低于年轻人。我们还发现，具有最明显感觉运动表征的参与者表现出最隔离的感觉运动网络。然而，只有感觉运动网络隔离与感觉运动表现的个体差异有关，特别是在老年人中。这些新的发现将网络隔离与神经独特性联系起来，但也表明网络隔离可能在随着年龄的增长保持感觉运动性能方面发挥更大的作用。
Normal aging is associated with declines in sensorimotor function. Previous studies have linked age-related behavioral declines to decreases in neural differentiation (i.e., dedifferentiation), including decreases in the distinctiveness of neural activation patterns and in the segregation of large-scale neural networks at rest. However, no studies to date have explored the relationship between these two neural measures and whether they explain the same aspects of behavior. To investigate these issues, we collected a battery of sensorimotor behavioral measures in older and younger adults and estimated (a) the distinctiveness of neural representations in sensorimotor cortex and (b) sensorimotor network segregation in the same participants. Consistent with prior findings, sensorimotor representations were less distinct and sensorimotor resting state networks were less segregated in older compared to younger adults. We also found that participants with the most distinct sensorimotor representations exhibited the most segregated sensorimotor networks. However, only sensorimotor network segregation was associated with individual differences in sensorimotor performance, particularly in older adults. These novel findings link network segregation to neural distinctiveness, but also suggest that network segregation may play a larger role in maintaining sensorimotor performance with age.
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DOI：
10.1523/jneurosci.0853-10.2010
发表时间：
2010-07-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Park J;Carp J;Hebrank A;Park DC;Polk TA
通讯作者：
Polk TA
DOI：
10.1111/j.1469-8749.2010.03766.x
发表时间：
2010-12-01
影响因子：
3.8
作者：
Koerte, Inga;Eftimov, Lara;Danek, Adrian
通讯作者：
Danek, Adrian
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
3.7
作者：
Mormino, Elizabeth C.;Smiljic, Andre;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
8.2
作者：
Seidler, Rachael D.;Bernard, Jessica A.;Burutolu, Taritonye B.;Fling, Brett W.;Gordon, Mark T.;Gwin, Joseph T.;Kwak, Youngbin;Lipps, David B.
通讯作者：
Lipps, David B.