Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.
Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.
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DOI：
10.1016/j.jhep.2010.03.029
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发表时间：
2010-09
影响因子：
25.7
通讯作者：
Halsted, Charles H.
中科院分区：
文献类型：
--
作者：
Medici, Valentina;Peerson, Janet M.;Stabler, Sally P.;French, Samuel W.;Gregory, Jesse F., III;Virata, Maria Catrina;Albanese, Antony;Bowlus, Christopher L.;Devaraj, Sridevi;Panacek, Edward A.;Rahim, Nazir;Richards, John R.;Rossaro, Lorenzo;Halsted, Charles H.
尽管肝脏蛋氨酸代谢异常在实验性酒精性肝病 (ALD) 的发病机制中起着核心作用，但其与临床 ALD 的风险和严重程度的关系尚不清楚。本临床研究的目的是确定慢性酗酒者血清蛋氨酸代谢物水平与 ALD 风险和病理严重程度之间的关系。检测 40 例 ALD 患者的肝功能生化标志物、维生素 B6、维生素 B12、叶酸、同型半胱氨酸、蛋氨酸、S-腺苷甲硫氨酸、S-腺苷同型半胱氨酸、胱硫醚、半胱氨酸、α-氨基丁酸、甘氨酸、丝氨酸和二甲基甘氨酸的水平，其中 24 例患有酒精性肝病 (ALD) 患者。 肝活检显示，26 名活跃饮酒者无肝病，28 名健康受试者。所有酗酒者的血清同型半胱氨酸均升高，而 ALD 患者维生素 B6 水平较低，胱硫醚升高，α-氨基丁酸/胱硫醚比率降低，这与维生素 B6 依赖性胱硫醚酶活性降低一致。 α-氨基丁酸/胱硫醚比率可预测 ALD 的存在，而胱硫醚与所有 ALD 患者的纤维化阶段相关。 α-氨基丁酸/胱硫醚比率对 ALD 存在的预测作用以及胱硫醚血清水平与纤维化严重程度之间的相关性表明同型半胱氨酸转硫途径在 ALD 中的重要性，并可能具有重要的诊断和治疗意义。
Although abnormal hepatic methionine metabolism plays a central role in the pathogenesis of experimental alcoholic liver disease (ALD), its relationship to the risk and severity of clinical ALD is not known. The aim of this clinical study was to determine the relationship between serum levels of methionine metabolites in chronic alcoholics and the risk and pathological severity of ALD. Serum levels of liver function biochemical markers, vitamin B6, vitamin B12, folate, homocysteine, methionine, S-adenosylmethionine, S-adenosylhomocysteine, cystathionine, cysteine, α-aminobutyrate, glycine, serine, and dimethylglycine were measured in 40 ALD patients, of whom 24 had liver biopsies, 26 were active drinkers without liver disease, and 28 were healthy subjects. Serum homocysteine was elevated in all alcoholics, whereas ALD patients had low vitamin B6 with elevated cystathionine and decreased α-aminobutyrate/cystathionine ratios, consistent with decreased activity of vitamin B6 dependent cystathionase. The α-aminobutyrate/cystathionine ratio predicted the presence of ALD, while cystathionine correlated with the stage of fibrosis in all ALD patients. The predictive role of the α- aminobutyrate/cystathionine ratio for the presence of ALD and the correlation between cystathionine serum levels with the severity of fibrosis point to the importance of the homocysteine transsulfuration pathway in ALD and may have important diagnostic and therapeutic implications.
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影响因子：
3.8
作者：
González-Quintela, A;Dominguez-Santalla, MJ;Barrio, E
通讯作者：
Barrio, E
DOI：
10.1097/01.alc.0000169265.36440.ee
发表时间：
2005-06-01
影响因子：
3.2
作者：
Blasco, C;Caballería, J;Rodés, J
通讯作者：
Rodés, J
DOI：
10.1111/j.1530-0277.2007.00407.x
发表时间：
2007-07-01
影响因子：
3.2
作者：
Esfandiari, Farah;You, Min;Halsted, Charles H.
通讯作者：
Halsted, Charles H.
DOI：
10.1073/pnas.112336399
发表时间：
2002-07-23
影响因子：
11.1
作者：
Halsted, CH;Villanueva, JA;James, SJ
通讯作者：
James, SJ
DOI：
10.1111/j.1530-0277.2001.tb02355.x
发表时间：
2001-09-01
影响因子：
3.2
作者：
Myrick, H;Henderson, S;Anton, RF
通讯作者：
Anton, RF