Developmental changes in effective connectivity in the emerging core face network.
Developmental changes in effective connectivity in the emerging core face network.
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DOI：
10.1093/cercor/bhq215
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Johnson MH
中科院分区：
文献类型：
--
作者：
Cohen Kadosh K;Cohen Kadosh R;Dick F;Johnson MH
目前，人们对出生后大脑皮层功能网络的出现知之甚少，这些网络支持复杂的感知和认知技能，如面部处理。本研究探讨了年轻和年长的学龄儿童以及年轻人的核心皮层网络的出现，面部处理。参与者进行了3项功能性磁共振成像目标检测任务，其中他们必须在连续呈现的面部流中检测特定的面部身份，表情或眼睛注视方向。我们使用动态因果模型比较了人脸网络的连通性，并观察到它在童年时期逐渐出现。此外，我们发现，虽然功能性网络连接的相对强度在成人中受到任务需求的不同调制，但在年龄较大或年龄较小的儿童中没有这种网络调制。这些结果与3个年龄组的行为表现无关。我们认为，人脸网络的出现是由于该网络区域内的持续专业化和微调。目前的研究结果具有重要的意义，为未来的研究调查轨迹的大脑发育和皮质专业化无论是在典型的和神经系统发育的人群。
Little is currently known about the postnatal emergence of functional cortical networks supporting complex perceptual and cognitive skills, such as face processing. The present study examined the emergence of the core cortical network underlying face processing in younger and older school-age children as well as young adults. Participants performed 3 functional magnetic resonance imaging target detection tasks where they either had to detect a specific facial identity, expression, or direction of eye gaze in a stream of consecutively presented faces. We compared the connectivity of the face network using dynamic causal modelling and observed that it emerges gradually during childhood. Further, we found that while the relative strength of functional network connections were differentially modulated by task demands in adults, there was no such modulation of this network in either older or younger children. These results were independent of the behavioral performance in the 3 age groups. We suggest that the emergence of the face network is due to continuous specialization and fine-tuning within the regions of this network. The current results have important implications for future studies investigating trajectories of brain development and cortical specialization both in typically and atypically developing populations.
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3.2
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