Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
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DOI：
10.1093/brain/awab417
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发表时间：
2022-05-24
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影响因子：
--
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颞叶癫痫是一种常见的成人耐药性癫痫，主要是一种边缘网络疾病，与主要的单侧海马病理学相关。结构MRI通过映射（i）非典型半球间不对称;或（ii）区域萎缩，为颞叶癫痫相对于对照组的全脑灰质结构改变提供了体内窗口。然而，非典型不对称和区域萎缩措施的相似性和差异尚未得到系统的研究。在这里，我们使用多位点ENIGMA-Epilepsy数据集解决了这一差距，该数据集包括732名颞叶癫痫患者和1418名健康对照者的MRI脑形态学测量。我们比较了颞叶癫痫患者的灰质不对称和萎缩的空间分布，将其地形图与皮质微结构和功能连接的空间梯度进行了背景化，这些空间梯度是使用从人类连接组项目获得的207名健康对照和包含23名颞叶癫痫患者和53名健康对照的独立数据集计算的，并使用机器学习检查了临床相关性。我们确定了一个显着的分歧，在空间分布的非典型半球间不对称性和区域萎缩映射。前者揭示了颞叶边缘系统疾病的签名，而后者表现出弥漫性和双边模式。我们的研究结果在各个研究中心和患者中都是稳健的。皮质萎缩与病程和癫痫发作时的年龄显著相关，而不对称程度与这些临床变量无显著关系。我们的研究结果强调，映射的非典型半球间的不对称性和区域性萎缩挖掘到两个互补的方面颞叶癫痫相关的病理学，与前者揭示主要基板在同侧边缘电路和后者捕获双边疾病的影响。这些发现完善了我们对颞叶癫痫的神经病理学的概念，并可能为未来发现和验证颞叶癫痫的互补MRI生物标志物提供信息。Park等人使用多位点ENIGMA-Epilepsy数据集系统地比较了颞叶癫痫中非典型结构不对称和萎缩的空间模式。不典型的不对称性和萎缩表现出明显不同的地形，以及不同的协会与癫痫发作的持续时间和年龄。
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy. Park et al. systematically compare spatial patterns of atypical structural asymmetry and atrophy in temporal lobe epilepsy, using the multisite ENIGMA-Epilepsy dataset. Atypical asymmetry and atrophy show a markedly distinct topography, as well as divergent associations with epilepsy duration and age at seizure onset.
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影响因子：
5.7
作者：
Alexander-Bloch AF;Shou H;Liu S;Satterthwaite TD;Glahn DC;Shinohara RT;Vandekar SN;Raznahan A
通讯作者：
Raznahan A
影响因子：
5.7
作者：
Bonilha, L;Rorden, C;Li, LM
通讯作者：
Li, LM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.6
作者：
Berg, Anne T.;Berkovic, Samuel F.;Scheffer, Ingrid E.
通讯作者：
Scheffer, Ingrid E.
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC