A fatal case of hemophagocytic lymphohistiocytosis associated with gestational psittacosis without symptoms of pneumonia

A fatal case of hemophagocytic lymphohistiocytosis associated with gestational psittacosis without symptoms of pneumonia
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与妊娠期鹦鹉热相关的噬血细胞淋巴组织细胞增多症死亡一例,无肺炎症状

DOI:
10.1111/jog.15429
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发表时间:
2022
影响因子:
1.6
通讯作者:
Yanagihara Itaru
Yanagihara Itaru
中科院分区:
医学4区
文献类型:
--
作者:
Yoshimura Michinobu;Shimizu Kanako;Nakura Yukiko;Kawahara Kazumi;Katano Harutaka;Motooka Daisuke;Takeuchi Makoto;Nagamune Kisaburo;Imamura Yoshiaki;Nakamura Shota;Yasukawa Kiyoshi;Hasegawa Hideki;Yoshida Yoshio;Yanagihara Itaru

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鹦鹉热是一种由鹦鹉热衣原体引起的人畜共患传染病。大多数患者都有急性呼吸道症状和全身疾病。当C。鹦鹉热感染孕妇,会导致严重的临床表现,称为妊娠期鹦鹉热。在这里我们报告一例妊娠鹦鹉热。我们的病人没有呼吸道症状,尸检发现严重的胎盘炎。DNA和免疫组织化学分析均为阳性。福尔马林固定的石蜡包埋组织中的鹦鹉。胎盘中的衣原体DNA含量大约是肺部的100倍,因此,胎盘而不是肺可能是C。在怀孕期间发生鹦鹉热感染。我们无法确定感染源。妊娠期不明原因发热的鉴别诊断应考虑妊娠期鹦鹉热病,即使在没有呼吸道症状的情况下也是如此。
Psittacosis is a zoonotic infection caused byChlamydia psittaci. Most patients present with acute respiratory symptoms and systemic illness. WhenC. psittaciinfects pregnant women, it causes severe clinical manifestations called gestational psittacosis. Here we report a case of gestational psittacosis. Our patient lacked respiratory symptoms, and pathological postmortem examinations revealed severe placentitis. Both DNA and immunohistochemical analyses were positive forC. psittacifrom formalin‐fixed paraffin‐embedded tissues. The chlamydial DNA in the placenta was about 100 times more abundant than that in the lungs; therefore, the placenta rather than the lungs was the probable target of theC. psittaciinfection during this pregnancy. We could not identify the source of infection. Gestational psittacosis should be considered in the differential diagnosis for fever of unknown origin during pregnancy, even in cases lacking respiratory symptoms.
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