Endothelial modulation of vascular tone in isolated porcine and bovine basilar arteries.
Endothelial modulation of vascular tone in isolated porcine and bovine basilar arteries.
复制标题
离体猪和牛基底动脉血管张力的内皮调节。
DOI：
10.1292/jvms.56.947
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
A. Nishio
中科院分区：
文献类型：
--
作者：
A. Miyamoto;M. Matsumoto;A. Nishio
在离体猪和牛基底动脉中研究了血管张力的内皮依赖性调节。L-硝基精氨酸（NO合成酶抑制剂）和亚甲蓝（可溶性鸟苷酸环化酶抑制剂）增加，但吲哚美辛（环氧合酶抑制剂）降低了两个物种的基底动脉血管张力。缓激肽引起预收缩的猪基底动脉舒张，但不牛基底动脉。氟化钠（内皮G蛋白激活剂）产生的预收缩基底动脉从两个物种的松弛。缓激肽和氟化钠的作用完全取消内皮剥脱和显着抑制L-硝基精氨酸和亚甲蓝，但不被吲哚美辛。硝普钠（鸟苷酸环化酶激活剂）诱发舒张预收缩内皮剥脱基底动脉从两个物种。这些结果表明，在基底动脉血管张力的内皮依赖性调制有物种差异。
Endothelium-dependent modulation of vascular tone was investigated in isolated porcine and bovine basilar arteries. L-Nitro-arginine (NO synthase inhibitor) and methylene blue (soluble guanylate cyclase inhibitor) increased, but indomethacin (cyclooxygenase inhibitor) decreased the vascular tone in the basilar arteries from both species. Bradykinin evoked relaxation of precontracted porcine basilar artery, but not bovine basilar artery. Sodium fluoride (endothelial G-protein activator) produced relaxation of precontracted basilar arteries from both species. The effects of bradykinin and sodium fluoride were completely abolished by endothelial denudation and markedly inhibited by L-nitro-arginine and methylene blue, but not by indomethacin. Sodium nitroprusside (guanylate cyclase activator) evoked relaxation of precontracted endothelium-denuded basilar arteries from both species. These results suggest that there is species variation in endothelium-dependent modulation of vascular tone in the basilar artery.
影响因子：
--
作者：
KATUSIC, ZS;MARSHALL, JJ;VANHOUTTE, PM
通讯作者：
VANHOUTTE, PM