Gastrectomized Rats Respond with Exaggerated Hypercalcemia to Oral and Intravenous Calcium Loads because of Impaired Ability of Bone to Take Up Ca 2+
Gastrectomized Rats Respond with Exaggerated Hypercalcemia to Oral and Intravenous Calcium Loads because of Impaired Ability of Bone to Take Up Ca 2+
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由于骨吸收 Ca 2 的能力受损，胃切除大鼠对口服和静脉钙负荷出现过度高钙血症
DOI：
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发表时间：
2002
影响因子：
1.9
通讯作者：
R. Häkanson
中科院分区：
文献类型：
--
作者：
V. Surve;P. Höglund;R. Häkanson
背景：胃切除术（GX）导致骨质减少。本研究检验的假设是GX影响钙稳态，处理钙的能力受损导致GX诱发的骨质减少。方法：比较sham和GX大鼠术后1 ~ 2周、2 ~ 4个月口服或静脉注射cacl2后血钙离子的变化。结果：不同剂量口服cacl2使GX大鼠血Ca 2+升高高于SHAM大鼠，2 ~ 4个月后高于1 ~ 2周后。无论是SHAM还是GX，禁食（48 h）大鼠的升高幅度都大于喂养大鼠。SHAM大鼠对高剂量cacl2耐受良好，而GX大鼠在暴露于相当适度剂量时死亡，特别是在GX后2-4个月。静脉输注cacl2 （2500 w mol/kg/h）诱导GX大鼠血Ca 2+升高幅度大于SHAM大鼠。血液ca2 +数据的动力学分析显示，GX大鼠显示：1)中央分布室（血液）ca2 +消除清除率降低，2)外周分布室（所谓的骨液室）尺寸减小，3)室间清除率显著降低（Ca 2+从血液转移到骨骼）。2-4个月后效果明显。牺牲时，通过颅骨平面分析证实gx诱发的骨质减少，显示2-4个月后骨组织减少40%。结论：根据目前的数据，我们认为GX大鼠对口服和静脉注射ca2负荷的高钙血症反应是由于ca2 +从血液到骨骼的转移严重受损。我们认为，随着时间的推移，这种损伤会导致骨质减少。
Background: Gastrectomy (GX) causes osteopenia. The hypothesis tested in the present study is that GX affects Ca homeostasis and that an impaired ability to handle Ca contributes to the GX-evoked osteopenia. Methods: SHAM-operated and GX rats were compared with respect to changes in blood Ca 2+ after oral or intravenous loads of CaCl 2 1-2 weeks or 2-4 months after the operations. Results: Different doses of oral CaCl 2 raised blood Ca 2+ more in GX than in SHAM rats, more so after 2-4 months than after 1-2 weeks. The rise was greater in fasted (48 h) rats than in fed rats regardless of whether they were SHAM or GX. While SHAM rats tolerated high doses of CaCl 2 well, GX rats died when exposed to quite modest doses, particularly 2-4 months after GX. Intravenous infusion of CaCl 2 (2500 w mol/kg/h) induced a greater and steeper rise in blood Ca 2+ in GX rats than in SHAM rats. Kinetic analysis of the blood Ca 2+ data showed GX rats to display: 1) a decreased Ca 2+ elimination clearance from the central distribution compartment (blood), 2) a reduced size of the peripheral distribution compartment (the so-called bone fluid compartment), and 3) a spectacular decrease in the intercompartmental clearance (transfer of Ca 2+ from blood to bone). These effects were notably apparent after 2-4 months. At sacrifice, the GX-evoked osteopenia was confirmed by planimetric analysis of the calvariae, revealing 40% reduction of bone tissue after 2-4 months. Conclusions: Based on the present data we argue that GX rats respond with exaggerated hypercalcemia to oral and intravenous CaCl 2 loads because of a greatly impaired transfer of Ca 2+ from blood to bone. We suggest that with time this impairment results in osteopenia.
低膳食钙和钙补充剂对未成熟、生长大鼠钙代谢和骨骼的影响。
DOI：
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发表时间：
1988
期刊：
Bone and mineral
影响因子：
--
作者：
Thomas,ML;Ibarra,MJ;Solcher,B;Wetzel,S;Simmons,DJ
通讯作者：
Simmons,DJ
估计群体动力学。
影响因子：
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作者：
Beal,SL;Sheiner,LB
通讯作者：
Sheiner,LB
胃作为内分泌器官。
影响因子：
3.2
作者：
DelValle,J
通讯作者：
DelValle,J