On-going computation of whisking phase by mechanoreceptors
On-going computation of whisking phase by mechanoreceptors
复制标题
通过机械感受器持续计算搅拌阶段
DOI：
10.1038/nn.4221
复制
发表时间：
2016
影响因子：
25
通讯作者：
E. Ahissar
中科院分区：
文献类型：
--
作者：
A. Wallach;K. Bagdasarian;E. Ahissar
为了将空间意义赋予感觉信息，感觉器官的状态必须在神经系统中表示。在啮齿动物的振动系统中，搅拌周期阶段已被确定为关键坐标，并且在体感皮层中报告了基于阶段的触摸表示。在上行传入通路中，相位在何处以及如何被提取仍然未知。在麻醉大鼠中使用闭环接口，我们发现拂动阶段已经由初级振动传入以频率和幅度不变的方式编码。我们发现，对于自然约束的搅拌动力学，可以通过将每个受体调整到受限的运动学子空间来获得这种不变的相位编码。不变的相位编码保留在脑干中，其中脑干神经元过滤掉缓慢进化的偏移，而脑膜神经元则保留它。这些结果证明了传感器级别的准确、感知相关、基于机械的处理。
To attribute spatial meaning to sensory information, the state of the sensory organ must be represented in the nervous system. In the rodent's vibrissal system, the whisking-cycle phase has been identified as a key coordinate, and phase-based representation of touch has been reported in the somatosensory cortex. Where and how phase is extracted in the ascending afferent pathways remains unknown. Using a closed-loop interface in anesthetized rats, we found that whisking phase is already encoded in a frequency- and amplitude-invariant manner by primary vibrissal afferents. We found that, for naturally constrained whisking dynamics, such invariant phase coding could be obtained by tuning each receptor to a restricted kinematic subspace. Invariant phase coding was preserved in the brainstem, where paralemniscal neurons filtered out the slowly evolving offset, whereas lemniscal neurons preserved it. These results demonstrate accurate, perceptually relevant, mechanically based processing at the sensor level.
影响因子：
16.2
作者：
Lenschow, Constanze;Brecht, Michael
通讯作者：
Brecht, Michael