Infection, stem cells and cancer signals.
Infection, stem cells and cancer signals.
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DOI：
10.2174/138920111794295675
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发表时间：
2011-02-01
影响因子：
2.8
通讯作者：
Sell S
中科院分区：
文献类型：
--
作者：
Sell S
The association of cancer with preceding parasitic infections has been observed for over 200 years. Some such cancers arise from infection of tissue stem cells by viruses with insertion of viral oncogenes into the host DNA (mouse polyoma virus, mouse mammary tumor virus). In other cases the virus does not insert its DNA into the host cells, but rather commandeers the metabolism of the infected cells, so that the cells continue to proliferate and do not differentiate (human papilloma virus and cervical cancer). Cytoplasmic Epstein Barr virus infection is associated with a specific gene translocation (Ig/c-myc) that activates proliferation of affected cells (Burkitt lymphoma). In chronic osteomyelitis an inflammatory reaction to the infection appears to act through production of inflammatory cytokines and oxygen radical formation to induce epithelial cancers. Infection with Helicobacter pylori leads to epigenetic changes in methylation and infection by a parasite. Clonorchis sinensis also acts as a promoter of cancer of the bile ducts of the liver (cholaniocarcinoma). The common thread among these diverse pathways is that the infections act to alter tissue stem cell signaling with continued proliferation of tumor transit amplifying cells.
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影响因子：
14.5
作者：
Cheng J;DeCaprio JA;Fluck MM;Schaffhausen BS
通讯作者：
Schaffhausen BS
影响因子：
7.4
作者：
Damonte, Patrizia;Hodgson, J. Graeme;Borowsky, Alexander D.
通讯作者：
Borowsky, Alexander D.
DOI：
10.1073/pnas.80.12.3812
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DURST, M;GISSMANN, L;ZURHAUSEN, H
通讯作者：
ZURHAUSEN, H
影响因子：
64.5
作者：
ECKHART, W;HUTCHINSON, MA;HUNTER, T
通讯作者：
HUNTER, T
影响因子：
14.5
作者：
Allday MJ
通讯作者：
Allday MJ