ASSESSMENT OF MACULAR VASCULATURE OF CHILDREN WITH SICKLE CELL DISEASE COMPARED TO THAT OF HEALTHY CONTROLS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
ASSESSMENT OF MACULAR VASCULATURE OF CHILDREN WITH SICKLE CELL DISEASE COMPARED TO THAT OF HEALTHY CONTROLS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
复制标题
使用光学相干断层扫描血管造影对患有镰状细胞病的儿童的黄斑血管与健康对照的黄斑血管进行评估。
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
A. Ambresin
中科院分区：
文献类型：
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作者：
S. Roemer;C. Bergin;P. Kaeser;A. Ambresin
目的
本研究旨在使用光学相干断层扫描血管造影来描述患有纯合型镰状细胞病（SCD）的儿科患者眼睛的黄斑血管特征。
方法
这是一个关于 SCD 儿科患者眼睛的回顾性病例系列，其种族和年龄与健康人的眼睛相匹配。使用浅层毛细血管丛和深部毛细血管丛的光学相干断层扫描血管造影图像，测量非血流面积、血管密度和黄斑中心凹无血管区。比较了光学相干断层扫描血管造影和荧光素血管造影获得的重塑微血管中心凹结构。
结果
总共检查了 SCD 患者的 19 只眼睛和种族匹配的健康对照者的 18 只眼睛。所有病例的最佳矫正视力范围为 75 至 85 个字母。在 SCD 系列中，8 只眼睛在眼底镜检查中显示出视网膜病变的迹象。与对照组相比，SCD患者眼睛的中心凹无血管区明显扩大，中心凹血管密度降低8%，并且中心凹周围血管改变更多。
结论
SCD患者眼中心凹血管密度显着降低，中心凹无血管区面积显着增加。在患有 SCD 的儿科患者中也观察到中心凹周围毛细血管的一致结构变化。
PURPOSE
This study aims at describing the macular vascular features of the eyes of pediatric patients with the homozygous form of sickle cell disease (SCD) using optical coherence tomography angiography.
METHODS
This is a retrospective case series of eyes of pediatric patients with SCD, race- and age-matched to those of healthy individuals. Using optical coherence tomography angiography images of superficial capillary plexus and deep capillary plexus, the nonflow area, vascular density, and foveal avascular zone were measured. The remodeled microvascular foveal architectures obtained on optical coherence tomography angiography and fluorescein angiography were compared.
RESULTS
A total of 19 eyes of patients with SCD and 18 eyes of race-matched healthy controls were examined. The best-corrected visual acuity ranged from 75 to 85 letters in all cases. In the SCD series, 8 eyes displayed signs of retinopathy on funduscopy. The foveal avascular zone was significantly enlarged, the foveal vascular density was 8% lower, and there were more perifoveal vascular alterations in the eyes of patients with SCD compared to those of controls.
CONCLUSION
The foveal vascular density was significantly reduced and area of the foveal avascular zone was significantly increased in the eyes of patients with SCD. Consistent architectural changes in the perifoveal capillaries were also observed in the pediatric patients with SCD.
牙买加儿童的镰状细胞性视网膜病：队列研究的进一步观察。
DOI：
10.1136/bjo.72.10.727
发表时间：
1988
期刊：
The British journal of ophthalmology
影响因子：
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作者：
Talbot,JF;Bird,AC;Maude,GH;Acheson,RW;Moriarty,BJ;Serjeant,GR
通讯作者：
Serjeant,GR