A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength training.
A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength training.
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对高阻力、低容量吸气肌力量训练的抗高血压作用进行多项试验、回顾性分析。
DOI：
10.1152/japplphysiol.00425.2022
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Bailey,EFiona
中科院分区：
文献类型：
--
作者：
Craighead,DanielH;Tavoian,Dallin;Freeberg,KaitlinA;Mazzone,JosieL;Vranish,JenniferR;DeLucia,ClaireM;Seals,DouglasR;Bailey,EFiona
血压过高是心血管疾病的主要危险因素。在一项对5项试点试验的回顾性分析中，我们评估了18-82岁成人高阻力吸气肌力量训练（IMST）的降血压效果，以及IMST对最大吸气压力（PI MAX）的影响，最大吸气压力是衡量吸气肌力量和独立疾病危险因素的指标。参与者被随机分配到高阻力IMST （75% PI MAX）或低阻力假训练（15% PI MAX）（30次呼吸/天，5-7天/周，6周）。IMST组（n= 67）使收缩压（SBP）降低9±6 mmHg (P< 0.01)，舒张压（DBP）降低4±4 mmHg （P< 0.01）。imst相关的收缩压和舒张压降低在训练的第2周出现（分别为- 4±8 mmHg和- 3±6 mmHg， P≤0.01），并在6周的干预中持续存在。假手术组收缩压、舒张压无明显差异（n= 61, P < 0.05）。选择受试者特征稍微改变了IMST对BP的影响。收缩压降低与年龄有关（β= - 0.07±0.03；P= 0.04），舒张压降低与medication-naïve BP （β= - 3±1；P= 0.02）和初始舒张压升高有关（β= - 0.12±0.05；P= 0.04）。PI MAX在高阻力IMST和低阻力假训练时升高，其中高阻力IMST升高幅度更大（+ 20±17 vs + 6±14 cmh2o； P< 0.01）。PI MAX的增加与年龄（β= - 0.20±0.09；P= 0.03）和基线PI MAX （β= - 0.15±0.07；P= 0.04）呈适度负相关，但与收缩压或舒张压的降低无关。这些来自多个独立试验的汇编结果提供了迄今为止最有力的证据，证明高耐药IMST在成年男性和女性中引起临床显着的收缩压和舒张压降低，以及PI MAX增加。在年轻到老年的成年男性和女性中，6周的高阻力吸气肌力量训练可使随意的收缩压和舒张压分别降低9 mmHg和4 mmHg，在训练第2周时观察到最初的降低。考虑到受试者基线特征（即年龄、降压药和健康状况）对干预血压结果的影响很小，因此，吸气肌力量训练在广泛的成人降压中是有效的。
Above-normal blood pressure (BP) is a primary risk factor for cardiovascular diseases. In a retrospective analysis of five pilot trials, we assessed the BP-lowering effects of high-resistance inspiratory muscle strength training (IMST) in adults aged 18–82 years and the impact of IMST on maximal inspiratory pressure (PI MAX), a gauge of inspiratory muscle strength and independent disease risk factor. Participants were randomized to high-resistance IMST (75% PI MAX) or low-resistance sham (15% PI MAX) training (30 breaths/day, 5–7 days/wk, 6 wk). IMST (n= 67) reduced systolic BP (SBP) by 9±6 mmHg (P< 0.01) and diastolic BP (DBP) by 4±4 mmHg (P< 0.01). IMST-related reductions in SBP and DBP emerged by week 2 of training (− 4±8 mmHg and− 3±6 mmHg; P≤ 0.01, respectively) and continued across the 6-wk intervention. SBP and DBP were unchanged with sham training (n= 61, all P> 0.05). Select subject characteristics slightly modified the impact of IMST on BP. Greater reductions in SBP were associated with older age (β=− 0.07±0.03; P= 0.04) and greater reductions in DBP associated with medication-naïve BP (β=− 3±1; P= 0.02) and higher initial DBP (β=− 0.12±0.05; P= 0.04). PI MAX increased with high-resistance IMST and low-resistance sham training, with a greater increase from high-resistance IMST (+ 20±17 vs.+ 6±14 cmH 2 O; P< 0.01). Gains in PI MAX had a modest inverse relation with age (β=− 0.20±0.09; P= 0.03) and baseline PI MAX (β=− 0.15±0.07; P= 0.04) but not to reductions in SBP or DBP. These compiled findings from multiple independent trials provide the strongest evidence to date that high-resistance IMST evokes clinically significant reductions in SBP and DBP, and increases in PI MAX, in adult men and women.NEW & NOTEWORTHY In young-to-older adult men and women, 6 wk of high-resistance inspiratory muscle strength training lowers casual systolic and diastolic blood pressure by 9 mmHg and 4 mmHg, respectively, with initial reductions observed by week 2 of training. Given blood pressure outcomes with the intervention were only slightly altered by subject baseline characteristics (ie, age, blood pressure medication, and health status), inspiratory muscle strength training is effective in lowering blood pressure in a broad range of adults.
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影响因子：
56.9
作者：
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DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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King,CH;Lett,RR;Nanduri,J;elIbiary,S;Peters,PA;Olds,GR;Mahmoud,AA
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Mahmoud,AA
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DOI：
10.1016/0277-5379(85)90271-8
发表时间：
1985
期刊：
European journal of cancer & clinical oncology
影响因子：
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作者：
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DOI：
--
发表时间：
1986
期刊：
Biochimica et Biophysica Acta
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Q. Ahkong;J. Lucy
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