Noncoding RNAs in Apicomplexan Parasites: An Update.
Noncoding RNAs in Apicomplexan Parasites: An Update.
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DOI:
10.1016/j.pt.2020.07.006
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发表时间:
2020-10
影响因子:
9.6
通讯作者:
Kissinger, Jessica C.
中科院分区:
文献类型:
--
作者:
Li, Yiran;Baptista, Rodrigo P.;Kissinger, Jessica C.
Recent breakthroughs in high-throughput technologies, transcriptomics and advances in our understanding of gene regulatory networks have enhanced our perspective on the complex interplay between parasite and host. Non-coding RNA molecules have been implicated in critical roles covering a broad range of biological processes in the Apicomplexa. Processes that are affected range from parasite development to host-parasite interactions and include interactions with epigenetic machinery and other regulatory factors. Here we review recent progress involving non-coding RNAs and their functions in the Apicomplexa with a focus on three parasites: Plasmodium, Toxoplasma, and Cryptosporidium. We discuss the limitations and challenges of current methods applied to apicomplexan non-coding RNA study and discuss future directions in this exciting field.
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