Adult visual cortical plasticity.
Adult visual cortical plasticity.
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DOI：
10.1016/j.neuron.2012.06.030
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发表时间：
2012-07-26
期刊：
影响因子：
16.2
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Gilbert CD;Li W
视觉皮层具有依赖于经验的变化能力，或皮层可塑性，这种能力在整个生命中都会保留。可塑性被调用用于在感知学习期间编码信息，通过内部表示视觉环境的轮廓，这对于促进中间水平视觉-轮廓整合和表面分割是有用的。相同的机制对于CNS损伤后的功能恢复具有适应性价值，例如与中风或神经退行性疾病相关的功能恢复。初级视皮层（V1）可塑性的一个共同特征是连接整个视野中轮廓元素的关联域。关联场的回路包括由皮质锥体细胞形成的长距离水平连接丛。这些连接经历快速和旺盛的发芽和修剪，以响应感觉输入的去除，这可以解释视网膜病变后的地形重组。皮层回路的类似改变可能涉及知觉学习，在V1中观察到的变化可能代表了学习信息在整个大脑皮层中的编码方式。
The visual cortex has the capacity for experience dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate level vision - contour integration and surface segmentation. The same mechanisms have adaptive value for functional recovery after CNS damage, such as that associated with stroke or neurodegenerative disease. A common feature to plasticity in primary visual cortex (V1) is an association field that links contour elements across the visual field. The circuitry underlying the association field includes a plexus of long range horizontal connections formed by cortical pyramidal cells. These connections undergo rapid and exuberant sprouting and pruning in response to removal of sensory input, which can account for the topographic reorganization following retinal lesions. Similar alterations in cortical circuitry may be involved in perceptual learning, and the changes observed in V1 may be representative of how learned information is encoded throughout the cerebral cortex.
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