A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.
A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.
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非人灵长类动物垂直袖状胃切除术模型有助于人类肥胖的机制和转化研究。
DOI：
10.1016/j.isci.2021.103421
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发表时间：
2021-12-17
期刊：
影响因子：
5.8
通讯作者：
Graham ML
中科院分区：
文献类型：
--
作者：
Nugent JL;Singh A;Wirth KM;Oppler SH;Hocum Stone L;Janecek JL;Sheka AC;Kizy S;Moore MEG;Staley C;Hering BJ;Ramachandran S;Ikramuddin S;Graham ML
肥胖症的流行对总体发病率和死亡率有很大影响。减肥手术是治疗肥胖和代谢功能障碍的黄金标准，但其发挥代谢益处的机制尚不清楚。在这里，我们展示了一个非人类灵长类(NHP)垂直袖状胃切除术(VSG)的模型，它模仿了人类的复杂性和结果。我们还表明，VSG可以减轻体重和持久的代谢益处，而SHAMS中等量的卡路里摄入量会导致手术后显著的体重增加。此外，我们还发现，VSG与早期体重无关的胆汁酸、短链脂肪酸的增加以及内脏脂肪组织(VAT)炎症的减轻有关，因为VAT驻留的免疫细胞偏向高度调节的髓系细胞和Treg细胞。这些数据表明，这个具有很强平移性的NHP模型可以用来询问驱动成功干预的因素，以揭示生理系统之间的相互作用，并改进肥胖和代谢综合征的治疗。垂直袖状胃切除术(VSG)猴模型准确模拟人VSG VSG可提供持久的代谢益处VSG降低冠状结构密度并改变VSG免疫学、肥胖学、外科学中代谢产物和免疫细胞群的巨噬细胞表型相互作用
The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome. A monkey model of vertical sleeve gastrectomy (VSG) accurately mimics human VSG VSG confers durable metabolic benefits VSG decreases crown-like structure density and alters macrophage phenotype Interplay of metabolites and immune cell populations in VSG Immunology; Obesity medicine; Surgery
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
16.2
作者：
Batterham, Rachel L.;Cummings, David E.
通讯作者：
Cummings, David E.
DOI：
10.1186/2045-5380-1-9
发表时间：
2011-11-07
期刊：
Biology of mood & anxiety disorders
影响因子：
--
作者：
Belzung C;Lemoine M
通讯作者：
Lemoine M
DOI：
10.1152/ajpendo.00469.2013
发表时间：
2014-02-01
影响因子：
5.1
作者：
Chambers, Adam P.;Smith, Eric P.;Sandoval, Darleen A.
通讯作者：
Sandoval, Darleen A.
影响因子：
11.5
作者：
Chou, Ken;Perry, Caroline M.
通讯作者：
Perry, Caroline M.