Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells.
Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells.
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DOI：
10.1038/srep02953
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发表时间：
2013-10-16
影响因子：
4.6
通讯作者：
Khizroev, Sakhrat
中科院分区：
文献类型：
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作者：
Guduru, Rakesh;Liang, Ping;Runowicz, Carolyn;Nair, Madhavan;Atluri, Venkata;Khizroev, Sakhrat
能够高特异性靶向递送抗肿瘤药物的纳米技术将是一般癌症特别是卵巢癌的重大突破。我们通过一种新的物理概念来解决这一挑战，该概念利用了（i）肿瘤细胞和健康细胞之间的膜电特性差异以及（ii）磁电纳米颗粒（MEN）作为远程磁场能量到MEN固有电场能量的纳米级转换器的能力。这种能力允许远程控制膜电场，从而通过创建局部纳米电穿孔位点来触发高特异性药物摄取。在对人卵巢癌细胞（SKOV-3）和健康细胞（HOMEC）系的体外研究中，我们应用30-Oe直流电场来触发负载在30-nm CoFe2O4@BaTiO3 MEN上的紫杉醇的高特异性摄取。药物穿透膜，在24小时内完全根除肿瘤，而不影响正常细胞。
The nanotechnology capable of high-specificity targeted delivery of anti-neoplastic drugs would be a significant breakthrough in Cancer in general and Ovarian Cancer in particular. We addressed this challenge through a new physical concept that exploited (i) the difference in the membrane electric properties between the tumor and healthy cells and (ii) the capability of magneto-electric nanoparticles (MENs) to serve as nanosized converters of remote magnetic field energy into the MENs' intrinsic electric field energy. This capability allows to remotely control the membrane electric fields and consequently trigger high-specificity drug uptake through creation of localized nano-electroporation sites. In in-vitro studies on human ovarian carcinoma cell (SKOV-3) and healthy cell (HOMEC) lines, we applied a 30-Oe d.c. field to trigger high-specificity uptake of paclitaxel loaded on 30-nm CoFe2O4@BaTiO3 MENs. The drug penetrated through the membrane and completely eradicated the tumor within 24 hours without affecting the normal cells.
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影响因子：
10.8
作者：
Kocbek, Petra;Obermajer, Natasa;Kristl, Julijana
通讯作者：
Kristl, Julijana
影响因子：
3.7
作者：
Lin, YH;Cai, N;Nan, CW
通讯作者：
Nan, CW
DOI：
10.1073/pnas.90.22.10504
发表时间：
1993-11-15
影响因子：
11.1
作者：
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通讯作者：
WEAVER, JC
影响因子：
15
作者：
Tong, Rong;Hemmati, Houman D.;Langer, Robert;Kohane, Daniel S.
通讯作者：
Kohane, Daniel S.
影响因子：
9
作者：
通讯作者：
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