Portulaca oleracea polysaccharides reduce serum lipid levels in aging rats by modulating intestinal microbiota and metabolites.
Portulaca oleracea polysaccharides reduce serum lipid levels in aging rats by modulating intestinal microbiota and metabolites.
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马齿苋多糖通过调节肠道微生物群和代谢物降低衰老大鼠的血脂水平
DOI：
10.3389/fnut.2022.965653
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发表时间：
2022
影响因子：
5
通讯作者：
Huang, Xiaoliu
中科院分区：
文献类型：
--
作者：
Fu, Qiang;Huang, Hui;Ding, Aiwen;Yu, Ziqi;Huang, Yuping;Fu, Guiping;Huang, Yushan;Huang, Xiaoliu
Metabolic diseases characterized by dyslipidemia are common health problems for elderly populations. Dietary fiber intake is inversely associated with the risk of dyslipidemia. This study investigated the effects of Portulaca oleracea polysaccharide (POP) on the intestinal microbiota and its metabolites in aging rats using 16S rRNA sequencing and metabolomics techniques. Our results showed that POPs reduced the ratio of Firmicutes/Bacteroidetes (F/B), relative abundance of Fusobacteria, and levels of triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and gamma-glutamyl transferase (γ-GT) in the serum of aging rats. POP supplementation also reduced 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol, and vaccenic acid concentrations in lipids and lipoid-like molecules, while soyasapogenol E and monoacylglycerol (MG) (24:0/0:0/0:0) levels increased. This study demonstrated that POP’s beneficial effects on lipid levels in aging rats might be partially attributable to the modification of gut microbiota and related metabolites.
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影响因子：
5.6
作者：
Gong F;Li F;Zhang L;Li J;Zhang Z;Wang G
通讯作者：
Wang G
影响因子：
12.2
作者：
Holscher HD
通讯作者：
Holscher HD
影响因子：
5.9
作者：
Fu J;Xu K;Ni X;Li X;Zhu X;Xu W
通讯作者：
Xu W
DOI：
10.3390/antiox11040695
发表时间：
2022-03-31
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.1
作者：
Chen, Guijie;Chen, Dan;Yuan, Qingxia
通讯作者：
Yuan, Qingxia