Effects of cannabidiol in cannabis flower: Implications for harm reduction.
Effects of cannabidiol in cannabis flower: Implications for harm reduction.
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DOI：
10.1111/adb.13092
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
Hutchison, Kent E.
中科院分区：
文献类型：
--
作者：
Gibson, Laurel P.;Karoly, Hollis C.;Ellingson, Jarrod M.;Klawitter, Jost;Sempio, Cristina;Squeri, Julia E.;Bryan, Angela D.;Bidwell, L. Cinnamon;Hutchison, Kent E.
使用联邦兼容的，自然的家庭管理程序，本研究检查了三种大麻花化学变化的急性影响，具有不同的四氢大麻酚（THC）与大麻二酚（CBD）的比例，以测试具有较高CBD含量的化学变化是否产生不同的影响。参与者被随机分配到三种化疗药物中的一种，（THC-主要：24%THC，1%CBD; THC+CBD：9%THC，10%CBD; CBD-主要：1%THC，23%CBD）; 159名经常吸食大麻的人（男性= 94，女性= 65）在任意给予其指定的化学变体之前、之后立即和之后1小时在移动的药理学实验室中进行评估。血浆大麻素以及阳性（例如，高，低）和负（例如，偏执和焦虑）的主观效应。与使用THC-显性化学变量的参与者相比，使用CBD-显性和THC + CBD化学变量的参与者在血浆样品中具有显著更少的THC和更多的CBD。此外，THC + CBD化学变异与类似水平的积极主观效应相关，但与THC占主导地位的化学变异相比，偏执和焦虑显着减少。这是使用在国家监管的市场中广泛使用的chemovars来检查各种THC与CBD比率的差异效应的首批研究之一。与仅使用THC的个体相比，使用THC + CBD化学变型的个体的血浆THC浓度显著降低，并且报告了较少的偏执和焦虑，同时还报告了类似的积极情绪效果，这从减少危害的角度来看是有趣的。需要进一步的研究来澄清大麻产品中CBD的危害减少潜力。
Using a federally compatible, naturalistic at-home administration procedure, the present study examined the acute effects of three cannabis flower chemovars with different tetrahydrocannabinol (THC) to cannabidiol (CBD) ratios, in order to test whether chemovars with a higher CBD content produce different effects. Participants were randomly assigned to ad libitum administration of one of three chemovars (THC-dominant: 24% THC, 1% CBD; THC+CBD: 9% THC, 10% CBD; CBD-dominant: 1% THC, 23% CBD); 159 regular cannabis users (male = 94, female = 65) were assessed in a mobile pharmacology lab before, immediately after, and 1 h after ad libitum administration of their assigned chemovar. Plasma cannabinoids as well as positive (e.g., high, elation) and negative (e.g., paranoia and anxiety) subjective effects were assessed at each time points. Participants who used the CBD-dominant and THC + CBD chemovars had significantly less THC and more CBD in plasma samples compared to participants who used the THC-dominant chemovar. Further, the THC + CBD chemovar was associated with similar levels of positive subjective effects, but significantly less paranoia and anxiety, as compared to the THC-dominant chemovar. This is one of the first studies to examine the differential effects of various THC to CBD ratios using chemovars that are widely available in state-regulated markets. Individuals using a THC + CBD chemovar had significantly lower plasma THC concentrations and reported less paranoia and anxiety while also reporting similar positive mood effects as compared to individuals using THC only, which is intriguing from a harm reduction perspective. Further research is needed to clarify the harm reduction potential of CBD in cannabis products.
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影响因子：
4.4
作者：
Korf, Dirk J.;Benschop, Annemieke;Wouters, Marije
通讯作者：
Wouters, Marije
影响因子：
6.8
作者：
Leweke FM;Piomelli D;Pahlisch F;Muhl D;Gerth CW;Hoyer C;Klosterkötter J;Hellmich M;Koethe D
通讯作者：
Koethe D
影响因子：
4.1
作者：
Englund, Amir;Morrison, Paul D.;Kapur, Shitij
通讯作者：
Kapur, Shitij
影响因子：
4.5
作者：
Hutchison, Kent E.;Bidwell, L. Cinnamon;Bryan, Angela D.
通讯作者：
Bryan, Angela D.
影响因子：
3.8
作者：
Bidwell, L. Cinnamon;Mueller, Raeghan;Hutchison, Kent E.
通讯作者：
Hutchison, Kent E.