Horizontal MicroRNA Transfer by Platelets - Evidence and Implications.
Horizontal MicroRNA Transfer by Platelets - Evidence and Implications.
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DOI：
10.3389/fphys.2021.678362
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发表时间：
2021
影响因子：
4
通讯作者：
Assinger A
中科院分区：
文献类型：
--
作者：
Mussbacher M;Pirabe A;Brunnthaler L;Schrottmaier WC;Assinger A
几十年来，血小板因其在止血中的核心作用及其释放生物活性分子的能力而闻名，从而允许血小板间通信以及与免疫系统和血管细胞的串扰。然而，随着血小板和血小板衍生微泡（MV）中microRNA的检测，揭示了细胞间调节的新水平。通过使MV从其质膜脱落，血小板能够释放功能性微小RNA复合物，该复合物被保护免受血浆RNA酶的影响。在与巨噬细胞、内皮细胞和平滑肌细胞接触时，血小板microRNA被快速内化，并通过转录后重编程微调受体细胞的功能。此外，通过血小板MV的microRNA转移允许渗透到具有有限细胞通路的组织如实体瘤中，从而它们不仅调节肿瘤进展，而且还提供了潜在的药物递送途径。了解血小板microRNA在生理和病理条件下水平转移的精确机制，可以设计侧特异性治疗（微）RNA递送系统。本文综述了目前的知识和科学证据的水平microRNA转移的血小板和血小板衍生的MV进入血管和非血管细胞及其生理后果。
For decades, platelets have been known for their central role in hemostasis and their ability to release bioactive molecules, allowing inter-platelet communication and crosstalk with the immune system and vascular cells. However, with the detection of microRNAs in platelets and platelet-derived microvesicles (MVs), a new level of inter-cellular regulation was revealed. By shedding MVs from their plasma membrane, platelets are able to release functional microRNA complexes that are protected from plasma RNases. Upon contact with macrophages, endothelial cells and smooth muscle cells platelet microRNAs are rapidly internalized and fine-tune the functionality of the recipient cell by post-transcriptional reprogramming. Moreover, microRNA transfer by platelet MVs allows infiltration into tissues with limited cellular access such as solid tumors, thereby they not only modulate tumor progression but also provide a potential route for drug delivery. Understanding the precise mechanisms of horizontal transfer of platelet microRNAs under physiological and pathological conditions allows to design side-specific therapeutic (micro)RNA delivery systems. This review summarizes the current knowledge and the scientific evidence of horizontal microRNA transfer by platelets and platelet-derived MVs into vascular and non-vascular cells and its physiological consequences.
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影响因子：
3.4
作者：
Beg MS;Brenner AJ;Sachdev J;Borad M;Kang YK;Stoudemire J;Smith S;Bader AG;Kim S;Hong DS
通讯作者：
Hong DS
影响因子：
20.3
作者：
Berger, G;Hartwell, DW;Wagner, DD
通讯作者：
Wagner, DD
影响因子：
64.5
作者：
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通讯作者：
Weyrich, AS
影响因子：
5.7
作者：
Aatonen, Maria;Gronholm, Mikaela;Siljander, Pia R. -M.
通讯作者：
Siljander, Pia R. -M.
影响因子：
9.3
作者：
Chim, Stephen S. C.;Shing, Tristan K. F.;Lo, Y. M. Dennis
通讯作者：
Lo, Y. M. Dennis