Altered Local Brain Amplitude of Fluctuations in Patients With Myotonic Dystrophy Type 1.
Altered Local Brain Amplitude of Fluctuations in Patients With Myotonic Dystrophy Type 1.
复制标题
1 型强直性肌营养不良患者局部脑波幅的改变
DOI：
10.3389/fnagi.2021.790632
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhou HY
中科院分区：
文献类型：
--
作者：
Huang P;Luan XH;Xie Z;Li MT;Chen SD;Liu J;Jia XZ;Cao L;Zhou HY
本研究旨在探讨 1 型强直性肌营养不良症 (DM1) 患者自发脑活动的特征。共有 18 名 DM1 患者和 18 名健康对照者 (HC) 通过静息态功能 MRI 进行了检查。组合方法包括低频波动幅度（ALFF）、低频波动分数幅度（fALFF）、标准化的基于小波变换的 ALFF（Wavelet-ALFF）、标准化/未标准化的波动百分比幅度（PerAF），用于评估 DM1 患者的自发脑活动。与HCs相比，DM1患者双侧楔前叶（PCUN）、角回（ANG）、顶下回、边缘上回和角回（IPL）、后扣带回（PCG）、额上回、内侧（SFGmed）、枕中回（MOG）的ALFF和小波-ALFF减少，主要分布在默认模式的脑区网络（DMN）。执行控制网络（ECN）的主要组成部分双侧额中回（MFG）、额下回、鳃盖部分（IFGoperc）也出现ALFF和小波-ALFF的减少。 DM1 患者的 SFGmed.R、右前扣带回和副扣带回 (ACGR)、双侧 MFG 中的 fALFF 也减少。 DM1 患者中，双侧 PCUN、ANG、PCG、MOG 和 IPLL 中的 PerAF 降低，以及 PCUNR 和双侧 PCG 中 PerAF 降低而未标准化。总之，DM1 患者的 DMN 和 ECN 活动降低，颞叶皮层和小脑波动增加。 DMN 中大脑活动的减少是最可重复和最可靠的，PCUN 和 PCG 是 DM1 患者脑功能障碍最特异性的成像生物标志物。
This study is aimed at investigating the characteristics of the spontaneous brain activity in patients with myotonic dystrophy type 1 (DM1). A total of 18 patients with DM1 and 18 healthy controls (HCs) were examined by resting-state functional MRI. Combined methods include amplitude of low-frequency fluctuations (ALFFs), the fractional amplitude of low-frequency fluctuations (fALFFs), and Wavelet transform-based ALFFs (Wavelet-ALFFs) with standardization, percent amplitude of fluctuation (PerAF) with/without standardization were applied to evaluate the spontaneous brain activity of patients with DM1. Compared with HCs, patients with DM1 showed decreased ALFFs and Wavelet-ALFFs in the bilateral precuneus (PCUN), angular gyrus (ANG), inferior parietal, but supramarginal and angular gyri (IPL), posterior cingulate gyrus (PCG), superior frontal gyrus, medial (SFGmed), middle occipital gyrus (MOG), which were mainly distributed in the brain regions of default mode network (DMN). Decreased ALFFs and Wavelet-ALFFs were also seen in bilateral middle frontal gyrus (MFG), inferior frontal gyrus, opercular part (IFGoperc), which were the main components of the executive control network (ECN). Patients with DM1 also showed decreased fALFFs in SFGmed.R, the right anterior cingulate and paracingulate gyri (ACGR), bilateral MFG. Reduced PerAF in bilateral PCUN, ANG, PCG, MOG, and IPLL as well as decreased PerAF without standardization in PCUNR and bilateral PCG also existed in patients with DM1. In conclusion, patients with DM1 had decreased activity in DMN and ECN with increased fluctuations in the temporal cortex and cerebellum. Decreased brain activity in DMN was the most repeatable and reliable with PCUN and PCG being the most specific imaging biomarker of brain dysfunction in patients with DM1.
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影响因子：
5.7
作者：
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通讯作者：
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