Health benefits, risks, and cost-effectiveness of influenza vaccination of children.
Health benefits, risks, and cost-effectiveness of influenza vaccination of children.
复制标题
DOI：
10.3201/eid1210.051015
复制
发表时间：
2006-10
影响因子：
11.8
通讯作者：
Lieu TA
中科院分区：
文献类型：
--
作者：
Prosser LA;Bridges CB;Uyeki TM;Hinrichsen VL;Meltzer MI;Molinari NA;Schwartz B;Thompson WW;Fukuda K;Lieu TA
为6-23个月大的儿童接种疫苗，加上所有其他高危儿童，可能比为所有儿童接种流感疫苗更有效。我们估计，每年为非高危儿童接种灭活流感疫苗(IIV)的成本效益从为6-23个月儿童节省的每个质量调整生命年(QALY)12,000美元到为12-17岁儿童节省的每个QALY美元119,000美元不等。对于6-35个月的高危儿童(既有医疗条件)，接种IIV疫苗是节省成本的。对于3-17岁的高危儿童，接种疫苗的费用为每QALY 1,000-10,000美元。在5-17岁的非高危儿童中，减毒活流感疫苗与IIV具有类似的成本效益。在决定每年接种疫苗的经济效果时，风险状况比年龄更重要，随着儿童年龄的增加，接种疫苗的成本效益更低。因此，对所有儿童进行常规接种可能比对所有6-23个月大的儿童加上所有其他高危儿童接种疫苗的成本效益要低。
Vaccinating children aged 6–23 months, plus all other children at high-risk, will likely be more effective than vaccinating all children against influenza. We estimated cost-effectiveness of annually vaccinating children not at high risk with inactivated influenza vaccine (IIV) to range from US $12,000 per quality-adjusted life year (QALY) saved for children ages 6–23 months to $119,000 per QALY saved for children ages 12–17 years. For children at high risk (preexisting medical conditions) ages 6–35 months, vaccination with IIV was cost saving. For children at high risk ages 3–17 years, vaccination cost $1,000–$10,000 per QALY. Among children not at high risk ages 5–17 years, live, attenuated influenza vaccine had a similar cost-effectiveness as IIV. Risk status was more important than age in determining the economic effects of annual vaccination, and vaccination was less cost-effective as the child's age increased. Thus, routine vaccination of all children is likely less cost-effective than vaccination of all children ages 6–23 months plus all other children at high risk.
登录
查看更多内容
影响因子：
6.4
作者：
MONTO, AS;DAVENPORT, FM;FRANCIS, T
通讯作者：
FRANCIS, T
影响因子：
5.5
作者：
Nichol, KL
通讯作者：
Nichol, KL
影响因子：
5.1
作者：
Belshe, RB;Gruber, WC;Wolff, M
通讯作者：
Wolff, M
影响因子：
--
作者：
Ekwueme, DU;Strebel, PM;Livengood, JR
通讯作者：
Livengood, JR
影响因子：
120.7
作者：
MARGOLIS, HS;COLEMAN, PJ;AREVALO, JA
通讯作者：
AREVALO, JA